TCEA1
TCEA1 (transcription elongation factor A1) is a nuclear general transcription factor of the TFS-II family that helps RNA polymerase II elongate through arresting sites in DNA. It is also known as SII, TF2S, TFIIS, TCEA and GTF2S. Browse Assay Genie's current range of TCEA1 research reagents below, or read on for the biology behind the target.
TCEA1 is necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. These sites in DNA have the property of trapping a fraction of the elongating RNA polymerases that pass through them, producing locked ternary complexes. Cleavage of the nascent transcript by TCEA1, historically called S-II, allows elongation to resume from the new 3'-terminus.
The TCEA1 protein belongs to the TFS-II family and is classed by HGNC in the general transcription factors gene group. UniProt records its location as the nucleus, and NCBI Gene describes it as located in the nucleoplasm and as part of the transcription factor TFIID complex. It enables transcription elongation factor activity and is involved in transcription elongation by RNA polymerase II. The mouse and rat orthologs are both named Tcea1.
The literature uses several names for the same factor: SII, TF2S, TFIIS, TCEA and GTF2S. The previous HGNC name was transcription elongation factor A (SII), 1. Because it acts on stalled polymerase complexes, the TCEA1 gene and protein are studied in work on how transcription proceeds through difficult template regions.
TCEA1 is needed for efficient RNA polymerase II elongation past arresting sites, making it a core factor for studying elongation control.
Cleavage of the nascent transcript by TCEA1 lets elongation resume from a new 3'-terminus, a process studied in arrested ternary complexes.
As a member of the general transcription factors group, TCEA1 is relevant to studies of the basal RNA polymerase II machinery.
TCEA1 is described as part of the transcription factor TFIID complex and is located in the nucleoplasm, supporting work on nuclear assemblies.
TCEA1 is necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. These sites can trap elongating polymerases in locked ternary complexes. TCEA1 cleaves the nascent transcript, which allows elongation to resume from the new 3'-terminus.
TCEA1 is also called SII, TF2S, TFIIS, TCEA and GTF2S. Its previous HGNC name was transcription elongation factor A (SII), 1. UniProt lists the protein as transcription elongation factor A protein 1, and it belongs to the TFS-II family.
Yes. Orthologs named Tcea1 are recorded in both mouse and rat, so the gene can be studied in common rodent models. Check the datasheet of any product for its validated reactivity.
Other TFS-II family members, general transcription factors and RNA polymerase II components with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P23193; product specifications from Assay Genie datasheets.