MT-CYB
MT-CYB (mitochondrially encoded cytochrome b, also known as COB, CYTB, UQCR3 and MTCYB) is a component of ubiquinol-cytochrome c reductase, or complex III, in the mitochondrial respiratory chain. It helps move electrons from ubiquinol to cytochrome c. Browse Assay Genie's current range of MT-CYB research reagents below, or read on for the biology behind the target.
The MT-CYB protein is a component of the ubiquinol-cytochrome c reductase complex, also called complex III or the cytochrome b-c1 complex, which forms part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. In doing so it contributes to the proton gradient across the mitochondrial membrane, which is then used for ATP synthesis. NCBI Gene annotation predicts that the protein enables electron transfer, metal ion binding and oxidoreductase activity, and that it contributes to quinol-cytochrome-c reductase activity.
Cytochrome b belongs to the cytochrome b family and is located in the mitochondrial inner membrane. The MT-CYB gene is unusual because it sits on the mitochondrial genome rather than in the nucleus. HGNC lists it within the mitochondrially encoded protein coding genes and within the complex III group of ubiquinol-cytochrome c reductase complex subunits. Researchers studying the MT-CYB gene therefore often work alongside other mitochondrially encoded respiratory chain genes, such as MT-CO2, MT-CO3, MT-ND1 and MT-ATP6.
The gene has carried several names in the literature. Current aliases include COB, CYTB, UQCR3 and MTCYB, and the previous HGNC name was simply cytochrome b. The mouse and rat orthologs are written Mt-Cyb and Mt-cyb. NCBI Gene summaries implicate MT-CYB in ovarian carcinoma and urinary bladder cancer, which makes it a point of interest for work on mitochondrial function in disease.
MT-CYB contributes to electron transfer from ubiquinol to cytochrome c in the respiratory chain, so it is a natural focus for studies of oxidative phosphorylation.
As a component of the cytochrome b-c1 complex, MT-CYB is relevant to work on how ubiquinol-cytochrome c reductase is assembled and functions.
MT-CYB is a mitochondrially encoded protein coding gene, which makes it relevant to studies of mitochondrial genome expression and its products.
MT-CYB is implicated in ovarian carcinoma and urinary bladder cancer, linking mitochondrial respiratory chain components to tumour research.
MT-CYB is a component of complex III, the ubiquinol-cytochrome c reductase complex of the mitochondrial respiratory chain. The complex mediates electron transfer from ubiquinol to cytochrome c and contributes to the proton gradient across the mitochondrial membrane that is used for ATP synthesis.
MT-CYB is the approved HGNC symbol for mitochondrially encoded cytochrome b. Aliases and previous symbols include COB, CYTB, UQCR3 and MTCYB, and the previous name was cytochrome b. UniProt lists the protein as cytochrome b, a member of the cytochrome b family.
Yes. The mouse ortholog is Mt-Cyb and the rat ortholog is Mt-cyb. The human gene is also linked to ovarian carcinoma and urinary bladder cancer in NCBI Gene; check the datasheet of any product for its validated reactivity.
Other mitochondrially encoded respiratory chain and ATP synthase genes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P00156; product specifications from Assay Genie datasheets.