THRSP
THRSP (thyroid hormone responsive, also known as SPOT14, S14, THRP, Lpgp and LPGP1) is a member of the SPOT14 family that helps regulate lipogenesis. It is best known for its role in triglyceride biosynthesis, particularly in lactating mammary gland. Browse Assay Genie's current range of THRSP research reagents below, or read on for the biology behind the target.
THRSP plays a role in the regulation of lipogenesis, especially in lactating mammary gland, and is important for the biosynthesis of triglycerides containing medium-length fatty acid chains. It is proposed to modulate lipogenesis by interacting with MID1IP1 and preventing MID1IP1 from interacting with ACACA. UniProt also notes that THRSP may function as a transcriptional coactivator and may modulate the transcription factor activity of THRB, consistent with its localisation to both the nucleus and the cytoplasm.
The THRSP gene encodes a protein belonging to the SPOT14 family, and the protein is annotated in UniProt as thyroid hormone-inducible hepatic protein. It is similar to the product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. Mouse and rat orthologs are both named Thrsp. In human tissue, the THRSP gene has been shown to be expressed in liver and in adipocytes, particularly in lipomatous nodules.
The alternative names reflect the history of the rat homolog: previous HGNC names include thyroid hormone responsive SPOT14 (rat) homolog and lipogenic protein 1. THRSP is also expressed in lipogenic breast cancers, which suggests a role in controlling tumour lipid metabolism. This makes THRSP protein a useful subject for studies of fatty acid and triglyceride synthesis in normal and malignant tissue.
THRSP helps regulate lipogenesis and the biosynthesis of triglycerides with medium-length fatty acid chains, making it relevant to studies of lipid synthesis.
The protein is implicated in lipogenesis in lactating mammary gland, linking it to the study of milk lipid production.
THRSP is expressed in lipogenic breast cancers, suggesting a role in controlling tumour lipid metabolism.
Its rat homolog is controlled by nutritional and hormonal factors, and THRSP may modulate THRB transcription factor activity.
THRSP regulates lipogenesis, especially in lactating mammary gland, and is important for synthesising triglycerides with medium-length fatty acid chains. It may act by binding MID1IP1 and blocking its interaction with ACACA. It may also act as a transcriptional coactivator and modulate THRB activity.
THRSP is also called SPOT14, S14, THRP, Lpgp and LPGP1. Earlier HGNC names were thyroid hormone responsive SPOT14 (rat) homolog and lipogenic protein 1. UniProt lists the protein as thyroid hormone-inducible hepatic protein, a member of the SPOT14 family.
THRSP is expressed in lipogenic breast cancers, suggesting a role in tumour lipid metabolism. It is similar to rat S14, and both mouse and rat carry orthologs named Thrsp. Check the datasheet of any product for its validated reactivity.
Interaction partners and lipogenesis-related proteins connected to THRSP function, including THRB, ACACA and MID1IP1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92748; product specifications from Assay Genie datasheets.