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PIPOX
PIPOX (pipecolic acid and sarcosine oxidase, also known as LPIPOX and formerly pipecolic acid oxidase) is a peroxisomal flavoprotein oxidase that metabolises sarcosine and L-pipecolic acid. UniProt lists it as peroxisomal sarcosine oxidase. Browse Assay Genie's current range of PIPOX research reagents below, or read on for the biology behind the target.
PIPOX is an oxidase that metabolises two substrates: sarcosine and L-pipecolic acid. The NCBI Gene summary describes it as enabling both L-pipecolate oxidase activity and sarcosine oxidase activity, which is why the enzyme carries two EC numbers, 1.5.3.1 and 1.5.3.7. Researchers studying these activities may work with the PIPOX protein, a PIPOX antibody or a PIPOX ELISA kit to examine the enzyme in experimental systems.
The PIPOX gene encodes a protein that is located in the peroxisome. HGNC places it in the groups of flavoproteins and oxidoreductases, and UniProt assigns it to the MSOX/MTOX family. The mouse ortholog is Pipox. The enzyme is annotated as peroxisomal sarcosine oxidase in UniProt, reflecting its subcellular site and one of its two substrates.
The gene symbol was derived from the earlier name pipecolic acid oxidase, with LPIPOX recorded as an alias. The current HGNC name, pipecolic acid and sarcosine oxidase, reflects the dual substrate specificity. Gene annotation links the enzyme to the L-lysine catabolic process that proceeds to acetyl-CoA via L-pipecolate, a term now marked obsolete in the Gene Ontology. This makes PIPOX a useful subject for work on peroxisomal amino acid metabolism.
PIPOX is a peroxisome-located flavoprotein oxidase, making it a relevant subject for studies of peroxisomal oxidative metabolism.
The enzyme metabolises sarcosine and has sarcosine oxidase activity, so it is studied in work on how sarcosine is handled.
PIPOX shows L-pipecolate oxidase activity, which places it in research on L-pipecolic acid turnover.
Gene annotation connects PIPOX to L-lysine catabolism to acetyl-CoA via L-pipecolate, supporting pathway-focused studies.
PIPOX metabolises sarcosine and L-pipecolic acid. It has both sarcosine oxidase and L-pipecolate oxidase activity, and it is found in the peroxisome. Its annotation also links it to L-lysine catabolism via L-pipecolate.
HGNC names the gene pipecolic acid and sarcosine oxidase. LPIPOX is a recorded alias, and the earlier name was pipecolic acid oxidase. UniProt uses the protein name peroxisomal sarcosine oxidase, and the enzyme carries EC numbers 1.5.3.1 and 1.5.3.7.
A mouse ortholog, Pipox, is recorded for the human gene. UniProt places the protein in the MSOX/MTOX family. Check the datasheet of any product for its validated reactivity before using it with a given species.
Other peroxisomal enzymes, flavoprotein oxidases and amino acid metabolism targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9P0Z9; product specifications from Assay Genie datasheets.
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