TIMP4
TIMP4 (TIMP metallopeptidase inhibitor 4) is a secreted member of the TIMP family that inhibits matrix metalloproteinases. Also known as metalloproteinase inhibitor 4 and tissue inhibitor of metalloproteinase 4, it acts by binding the catalytic zinc cofactor of its target enzymes. Browse Assay Genie's current range of TIMP4 research reagents below, or read on for the biology behind the target.
TIMP4 forms complexes with metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9. Matrix metalloproteinases are peptidases involved in degradation of the extracellular matrix, so inhibitors of this kind help determine how much matrix turnover takes place in a tissue.
The TIMP4 gene belongs to the TIMP gene family and belongs to the protease inhibitor I35 (TIMP) family at the protein level. HGNC places it in the tissue inhibitor of metallopeptidases gene group. The encoded protein is secreted and contains a netrin domain. Mouse and rat both have a Timp4 ortholog, which allows the biology of this inhibitor to be examined in common model species.
According to the NCBI Gene summary, the TIMP4 protein is involved in regulation of platelet aggregation and recruitment, and may play a role in hormonal regulation and endometrial tissue remodelling. Its previous HGNC name was tissue inhibitor of metalloproteinase 4. Within the family it sits alongside TIMP-1, TIMP-2 and TIMP3, which are also inhibitors of the matrix metalloproteinases, making comparisons between family members a common starting point for studies of extracellular matrix control.
TIMP4 inhibits matrix metalloproteinases that degrade the extracellular matrix, making it relevant to studies of matrix turnover.
TIMP4 binds the catalytic zinc of MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9, providing a defined model of protease inhibition.
The protein is involved in regulation of platelet aggregation and recruitment, linking protease inhibition to platelet biology.
TIMP4 may play a role in hormonal regulation and endometrial tissue remodelling, an area of interest in reproductive tissue research.
TIMP4 is a secreted inhibitor of metalloproteinases. It forms complexes with enzymes such as collagenases and irreversibly inactivates them by binding their catalytic zinc cofactor. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9, and is involved in regulating platelet aggregation and recruitment.
The HGNC full name is TIMP metallopeptidase inhibitor 4, and the UniProt name is metalloproteinase inhibitor 4. The previous HGNC name was tissue inhibitor of metalloproteinase 4. No alternative gene symbols are listed. The gene sits in the tissue inhibitor of metallopeptidases group.
Yes. Both mouse and rat have an ortholog named Timp4, so the gene can be studied in common rodent models. Cross-species work should consider sequence differences, so check the datasheet of any product for its validated reactivity.
Other TIMP family members and the matrix metalloproteinases that TIMP4 inhibits, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99727; product specifications from Assay Genie datasheets.