CYP3A7
CYP3A7 (cytochrome P450 family 3 subfamily A member 7, also known as CP37 and P450-HFLA) is a cytochrome P450 monooxygenase that metabolises steroid hormones, retinoic acid and vitamins during embryogenesis. It also contributes to the oxidative metabolism of xenobiotics. Browse Assay Genie's current range of CYP3A7 research reagents below, or read on for the biology behind the target.
CYP3A7 is a cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, it uses molecular oxygen, inserting one oxygen atom into a substrate and reducing the second to water, with two electrons supplied by NADPH through cytochrome P450 reductase (NADPH--hemoprotein reductase). The enzyme catalyses the hydroxylation of carbon-hydrogen bonds.
Among its substrates, CYP3A7 metabolises dehydroepiandrosterone (DHEA), a precursor in the biosynthesis of androgen and oestrogen steroid hormones. It shows high catalytic activity for forming hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position. It mainly hydroxylates all-trans-retinoic acid (atRA) to 4-hydroxyretinoate and may therefore contribute to atRA clearance during foetal development. NCBI also reports that it hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. It is further implicated in the oxidative metabolism of xenobiotics, including anticonvulsants.
The CYP3A7 gene encodes a member of the cytochrome P450 superfamily, whose enzymes participate in drug metabolism and in the synthesis of cholesterol, steroids and other lipids. The gene lies in a cluster of related genes on chromosome 7q21.1 (HGNC lists 7q22.1). Naturally occurring readthrough transcription links it to the downstream CYP3A51P pseudogene. The protein is anchored in the endoplasmic reticulum and microsome membranes, and HGNC places it in the cytochrome P450 family 3 gene group. Earlier names include cytochrome P450, subfamily IIIA, polypeptide 7.
CYP3A7 metabolises DHEA, a precursor of androgens and oestrogens, and forms hydroxyestrogens from estrone, making it relevant to steroid biosynthesis studies.
The enzyme acts on steroid hormones and vitamins during embryogenesis and may contribute to atRA clearance in the fetus.
CYP3A7 mainly hydroxylates all-trans-retinoic acid to 4-hydroxyretinoate, a reaction of interest for retinoid homeostasis.
CYP3A7 takes part in the oxidative metabolism of xenobiotics, including anticonvulsants, as part of the wider P450 drug-metabolism system.
CYP3A7 is a cytochrome P450 monooxygenase that hydroxylates carbon-hydrogen bonds using oxygen and electrons from NADPH via cytochrome P450 reductase. It metabolises DHEA, estrone and all-trans-retinoic acid, and also acts on xenobiotics such as anticonvulsants, with a role during embryogenesis.
CYP3A7 is also known as CP37 and P450-HFLA. Its UniProt name is cytochrome P450 3A7, and older HGNC names include cytochrome P450, subfamily IIIA, polypeptide 7. The enzyme is classified as EC 1.14.14.1. Readthrough transcription with CYP3A51P is represented by a separate gene entry.
CYP3A7 belongs to the cytochrome P450 family and the HGNC cytochrome P450 family 3 gene group. It sits in a cluster of related genes on chromosome 7. Ortholog information for mouse and rat is not given in the source data; check the datasheet of any product for its validated reactivity.
Other cytochrome P450 enzymes involved in drug, steroid and retinoid metabolism with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P24462; product specifications from Assay Genie datasheets.