SAA4
SAA4 (serum amyloid A4, constitutive) is a secreted member of the serum amyloid A family, annotated in UniProt as a major acute phase reactant. It is also known by the aliases C-SAA and CSAA. Browse Assay Genie's current range of SAA4 research reagents below, or read on for the biology behind the target.
SAA4, the serum amyloid A-4 protein, is described in UniProt as a major acute phase reactant. Acute phase reactants are proteins whose circulating levels shift during the acute-phase response, and the NCBI Gene summary likewise predicts that the SAA4 gene is involved in this response. The protein is secreted, and NCBI Gene reports it as located in extracellular exosomes.
The SAA4 gene is found at 11p15.1 and encodes a protein that belongs to the SAA family. The symbol is approved by HGNC as serum amyloid A4, constitutive, and the aliases C-SAA and CSAA are in use. The word "constitutive" in the full name is the basis of the C-SAA alias. The mouse ortholog is named Saa4, which allows comparative work in mouse models.
For researchers, SAA4 is a reference point within the wider SAA family when studying acute-phase biology and secreted proteins. The source annotations are brief, so the specific mechanism of SAA4 should be confirmed in the primary literature before assay design. Researchers working with the SAA4 protein, whether by antibody-based detection or ELISA, should also consider related SAA family members when interpreting results.
SAA4 is annotated as a major acute phase reactant, making it relevant to studies of how the acute-phase response is characterised.
As a member of the SAA family, SAA4 provides a point of comparison with other serum amyloid A proteins.
SAA4 is secreted and reported as located in extracellular exosomes, which is relevant to extracellular vesicle and secreted protein research.
The mouse ortholog Saa4 supports comparative investigation of SAA4 biology in murine experimental systems.
UniProt annotates SAA4 as a major acute phase reactant, and NCBI Gene predicts its involvement in the acute-phase response. The protein is secreted and has been reported in extracellular exosomes. Detailed molecular mechanisms are not given in these sources.
The HGNC full name is serum amyloid A4, constitutive, and UniProt lists it as serum amyloid A-4 protein. The aliases are C-SAA and CSAA. HGNC records no previous names or symbols beyond these aliases.
A mouse ortholog, Saa4, is recorded for the human gene. SAA4 belongs to the SAA family, which includes related serum amyloid A proteins. Check the datasheet of any product for its validated reactivity.
Other serum amyloid A family and related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35542; product specifications from Assay Genie datasheets.