MUC12
MUC12 (mucin 12, cell surface associated) is an integral membrane glycoprotein of the mucin family, previously known as MUC11 or mucin 11. It contributes to epithelial cell protection, adhesion modulation and signalling at mucosal surfaces. Browse Assay Genie's current range of MUC12 research reagents below, or read on for the biology behind the target.
MUC12 is involved in epithelial cell protection, modulation of adhesion and signalling, and may also take part in the regulation of epithelial cell growth. As a mucin, it belongs to a group of O-glycosylated proteins that help form protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. Mucins also contribute to intracellular signalling, a role shared by this protein. In intestinal epithelium, MUC12 is stimulated by both the cytokine TNF and TGF-beta.
The MUC12 gene encodes an integral membrane glycoprotein that is expressed on the apical membrane surface of epithelial cells lining mucosal surfaces in many tissues, including the colon, pancreas, prostate and uterus. HGNC classifies it within the mucins and the SEA domain containing groups, and UniProt records its subcellular location as membrane. This places MUC12 at the interface between the epithelium and the external environment, in contrast to secreted gel-forming mucins.
The gene was formerly designated MUC11, and its previous name was mucin 11. Expression of the gene is downregulated in colorectal cancer tissue, which makes MUC12 a point of interest for researchers studying intestinal epithelial biology, mucosal barrier function and the changes that accompany colorectal tumorigenesis. Studies of MUC12 protein often sit alongside other membrane-associated mucins, so that their distinct and overlapping roles at epithelial surfaces can be compared.
Mucins form protective mucous barriers on epithelial surfaces, and MUC12 is an apical membrane mucin involved in epithelial cell protection.
MUC12 expression is downregulated in colorectal cancer tissue, making it relevant to studies of tumour-associated changes in the intestinal epithelium.
MUC12 is implicated in adhesion modulation and signalling, and may help regulate epithelial cell growth, renewal and differentiation.
MUC12 is stimulated by TNF and TGF-beta in intestinal epithelium, supporting work on cytokine-driven regulation of mucosal surfaces.
MUC12 is involved in epithelial cell protection, adhesion modulation and signalling, and may help regulate epithelial cell growth. As a mucin, it contributes to the protective barrier on mucosal surfaces. In intestinal epithelium it is stimulated by both TNF and TGF-beta.
Yes. MUC11 is a previous symbol for the gene, and mucin 11 is its previous name. The current HGNC symbol is MUC12, with the approved name mucin 12, cell surface associated. UniProt lists the protein as Mucin-12. Both names may appear in older literature.
The NCBI Gene summary reports that MUC12 expression is downregulated in colorectal cancer tissue. The protein is normally found on the apical surface of epithelial cells in tissues such as the colon, pancreas, prostate and uterus. Check the datasheet of any product for its validated reactivity.
Other membrane-bound and secreted mucins involved in epithelial barrier function and mucosal biology, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UKN1; product specifications from Assay Genie datasheets.