ADCK5
ADCK5 (aarF domain containing kinase 5, also known as FLJ35454) is a member of the ADCK protein kinase family, within the protein kinase superfamily. Its function is not yet clear, and it is predicted to have protein serine/threonine kinase activity. Browse Assay Genie's current range of ADCK5 research reagents below, or read on for the biology behind the target.
ADCK5 belongs to the ADCK protein kinase family, part of the wider protein kinase superfamily. The function of the protein is not yet clear. UniProt notes that it is not known whether ADCK5 has protein kinase activity, or which type of substrate it would phosphorylate (serine, threonine or tyrosine). The NCBI Gene summary describes it as predicted to enable protein serine/threonine kinase activity, which is consistent with its enzyme classification as a protein kinase (EC 2.7.11.-), but this remains a prediction rather than an established property.
The ADCK5 gene encodes a protein listed in UniProt as an uncharacterized aarF domain-containing protein kinase 5. The protein is annotated as a membrane protein, and the NCBI Gene summary reports that it is located in the mitochondrion. The mouse ortholog is Adck5. Researchers studying ADCK5 protein therefore work with a target whose catalytic activity, substrates and cellular role are still open questions.
HGNC names the gene aarF domain containing kinase 5 and places it in the ADCK family. FLJ35454 is a recorded alias. Other family members, such as ADCK1 and ADCK2, are useful points of comparison when examining how the ADCK kinases relate to one another. Because the available annotation is limited, any work on ADCK5 benefits from careful controls and from confirming expression and localisation in the system under study.
ADCK5 is a predicted serine/threonine kinase of unclear function, making it a candidate for work on whether ADCK family members have genuine protein kinase activity.
The NCBI Gene summary places ADCK5 in the mitochondrion, so it is relevant to studies of mitochondrial proteins and their localisation.
As a member of the ADCK protein kinase family, ADCK5 supports comparative studies of the family within the protein kinase superfamily.
UniProt annotates ADCK5 as a membrane protein, and its substrates and cellular role remain to be defined.
The function of ADCK5 is not yet clear. UniProt states it is unknown whether it has protein kinase activity or which residue type (Ser, Thr or Tyr) it would phosphorylate. The NCBI Gene summary says it is predicted to enable protein serine/threonine kinase activity and is located in the mitochondrion.
ADCK5 is the HGNC symbol for aarF domain containing kinase 5. The recorded alias is FLJ35454. UniProt lists the protein as uncharacterized aarF domain-containing protein kinase 5, and HGNC assigns the gene to the ADCK family.
A mouse ortholog, Adck5, is recorded for the human gene. ADCK5 belongs to the ADCK protein kinase family, which includes ADCK1 and ADCK2 in humans. Check the datasheet of any product for its validated reactivity.
Other members of the ADCK protein kinase family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q3MIX3; product specifications from Assay Genie datasheets.