USF2
USF2 (upstream stimulatory factor 2) is a nuclear transcription factor of the basic helix-loop-helix leucine zipper family. It binds the symmetrical E-box sequence 5'-CACGTG-3' and is also known as FIP and bHLHb12. Browse Assay Genie's current range of USF2 research reagents below, or read on for the biology behind the target.
USF2 is a transcription factor that binds a symmetrical DNA sequence, the E-box 5'-CACGTG-3', which is found in a variety of viral and cellular promoters. Through this binding it can regulate gene expression. According to the NCBI Gene summary, the encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements as well as E-box motifs, and it is involved in regulating multiple cellular processes.
The USF2 gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors, and HGNC places it in the group of basic helix-loop-helix proteins. The basic helix-loop-helix region provides DNA contact, while the leucine zipper is the feature of this family associated with dimerisation. The protein localises to the nucleus, consistent with its role in controlling transcription. Orthologous genes are present in the mouse and rat, both named Usf2, which allows the factor to be studied in common model systems.
The approved gene name, upstream transcription factor 2, c-fos interacting, is reflected in the alias FIP, while bHLHb12 reflects its position in the basic helix-loop-helix nomenclature. Researchers studying E-box-dependent transcription often consider USF2 alongside USF1, a related upstream stimulatory factor. Reagents for the USF2 protein and USF2 gene support work on promoter regulation and transcriptional control.
USF2 binds E-box elements and can activate transcription via E-box and Inr motifs, making it a model for promoter-level gene control.
The 5'-CACGTG-3' site recognised by USF2 occurs in many viral and cellular promoters, supporting analysis of DNA-protein interactions.
As a basic helix-loop-helix leucine zipper family member, USF2 is used to study how this class of transcription factors acts.
NCBI Gene notes that USF2 is involved in regulating multiple cellular processes, motivating study of its downstream targets.
USF2 is a transcription factor that binds the symmetrical E-box sequence 5'-CACGTG-3' found in many viral and cellular promoters. It can activate transcription through E-box motifs and pyrimidine-rich initiator (Inr) elements, and is involved in regulating multiple cellular processes.
USF2 stands for upstream stimulatory factor 2. The HGNC name is upstream transcription factor 2, c-fos interacting, and aliases include FIP and bHLHb12. Searching under any of these names should help when comparing literature or USF2 antibody and USF2 ELISA kit information.
Yes. Orthologues named Usf2 are listed for both mouse and rat, so the factor can be studied in these model organisms. Check the datasheet of any product for its validated reactivity.
USF1 and other E-box-binding basic helix-loop-helix transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15853; product specifications from Assay Genie datasheets.