PRB2
PRB2, also known as basic salivary proline-rich protein 2, is a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. It is secreted from the parotid glands and is also referred to as PRPPRB1, Ps or cP7. Browse Assay Genie's current range of PRB2 research reagents below, or read on for the biology behind the target.
PRB2 belongs to the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The protein is made as a preproprotein, which undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. This processing step means that a single PRB2 gene can give rise to several related secreted products.
The PRB2 gene is notable for its variability. Multiple alleles have been identified that differ in the length of their tandem repeats, in polymorphic cleavage sites and in polymorphic stop codons. Researchers working with the PRB2 protein, or designing a PRB2 antibody or PRB2 ELISA kit experiment, should therefore take allelic variation and processing into account when interpreting results.
HGNC places the gene in the proline rich proteins group, under the name proline rich protein BstNI subfamily 2. Earlier or alternative designations include PRPPRB1, Ps and cP7. The PRB2 gene sits within a cluster of closely related salivary proline-rich protein genes on chromosome 12, alongside neighbours such as PRB1 and PRB4, which makes it a useful point of comparison when studying this gene cluster.
PRB2 is a basic, proline-rich glycoprotein secreted from the parotid glands, making it a relevant subject for studies of human salivary composition.
The PRB2 preproprotein is cleaved to yield one or more mature isoforms before secretion, providing a model for processing of salivary proteins.
Alleles of PRB2 vary in tandem repeat length, cleavage sites and stop codons, supporting work on variation within repetitive gene families.
PRB2 lies in a cluster of closely related salivary proline-rich protein genes on chromosome 12, enabling comparison between family members.
PRB2 encodes a basic, proline-rich human salivary glycoprotein. The preproprotein is proteolytically processed into one or more mature isoforms and then secreted from the parotid glands. The source annotation available here does not describe a more specific molecular function.
PRB2 is also known as basic salivary proline-rich protein 2, proline rich protein BstNI subfamily 2, PRPPRB1, Ps and cP7. Processing of the preproprotein produces one or more mature isoforms, and several alleles with differing repeat lengths have been described.
Yes. Multiple PRB2 alleles have been identified, differing in tandem repeat length, polymorphic cleavage sites and polymorphic stop codons. The gene is part of a cluster of closely related salivary proline-rich protein genes on chromosome 12. Check the datasheet of any product for its validated reactivity.
Other members of the salivary proline-rich protein gene cluster on chromosome 12 with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P02812; product specifications from Assay Genie datasheets.