NKX2-2
NKX2-2 (NK2 homeobox 2, also known as NKX2.2 or NKX2B) is a nuclear homeobox transcription factor of the NK-2 family. It acts as a transcriptional activator in the development of insulin-producing beta cells in the endocrine pancreas. Browse Assay Genie's current range of NKX2-2 research reagents below, or read on for the biology behind the target.
NKX2-2 is a transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas. It binds to elements within the NEUROD1 promoter, which places it within the regulatory network that controls endocrine cell differentiation. The NKX2-2 protein may also help specify diencephalic neuromeric boundaries and control the expression of genes that play a role in axonal guidance.
The NKX2-2 gene encodes a protein with a homeobox domain, and the protein is likely to be a nuclear transcription factor. UniProt places it in the NK-2 homeobox family, and HGNC classifies the gene within the NKL subclass homeoboxes and pseudogenes. NCBI Gene notes that it may be involved in the morphogenesis of the central nervous system, consistent with its proposed roles in diencephalic patterning and axonal guidance. The mouse ortholog is Nkx2-2.
The NKX2-2 gene lies on chromosome 20 close to NKX2-4. According to the NCBI Gene summary, these two genes appear to be duplicated on chromosome 14 as TITF1 and NKX2-8, which reflects a shared evolutionary origin within the family. The gene has also been catalogued as NKX2.2 and NKX2B, and under the earlier names NK-2 (Drosophila) homolog B and NK2 transcription factor related, locus 2 (Drosophila). Researchers studying pancreatic development, neural patterning or homeobox gene evolution often work with the NKX2-2 protein and gene.
NKX2-2 is a transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas.
NKX2-2 may help specify diencephalic neuromeric boundaries and may be involved in the morphogenesis of the central nervous system.
NKX2-2 may control the expression of genes that play a role in axonal guidance.
NKX2-2 binds elements within the NEUROD1 promoter, making it a useful subject for homeobox transcription factor research.
NKX2-2 is a transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas. It binds elements within the NEUROD1 promoter. It may also help specify diencephalic neuromeric boundaries and control genes involved in axonal guidance.
NKX2-2 is also written NKX2.2 or NKX2B, and UniProt names the protein Homeobox protein Nkx-2.2. Earlier HGNC names were NK-2 (Drosophila) homolog B and NK2 transcription factor related, locus 2 (Drosophila).
NKX2-2 belongs to the NK-2 homeobox family. It lies near NKX2-4 on chromosome 20, and these two genes appear to be duplicated on chromosome 14 as TITF1 and NKX2-8. The mouse ortholog is Nkx2-2; check the datasheet of any product for its validated reactivity.
Other NK-family homeobox transcription factors and paralogues related to NKX2-2 with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95096; product specifications from Assay Genie datasheets.