RPL23A
RPL23A (ribosomal protein L23a, also known as L23A or uL23) is a component of the 60S large ribosomal subunit, the part of the ribosome that takes part in protein synthesis. It is encoded by a gene that also hosts several small nucleolar RNA genes. Browse Assay Genie's current range of RPL23A research reagents below, or read on for the biology behind the target.
RPL23A is a component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Ribosomes consist of a small 40S subunit and a large 60S subunit, which together contain four RNA species and approximately 80 structurally distinct proteins. The RPL23A protein is part of the 60S subunit and binds a specific region of the 26S rRNA; in yeast, the corresponding protein binds a specific site on this rRNA.
The RPL23A gene encodes a protein of the uL23 family, also referred to as the L23P family of ribosomal proteins. UniProt annotates the protein in the cytoplasm and nucleus, and the NCBI summary places it in the cytoplasm. HGNC classifies it among the L ribosomal proteins and among small nucleolar RNA protein coding host genes. The gene is co-transcribed with the U42A, U42B, U101A and U101B small nucleolar RNA genes, which lie in its third, first, second and fourth introns respectively. As is typical for ribosomal protein genes, multiple processed pseudogenes are dispersed through the genome, which is worth bearing in mind when designing nucleic acid assays. Orthologues are annotated in mouse and rat as Rpl23a.
Beyond its structural role, RPL23A may promote p53/TP53 degradation, possibly by stimulating MDM2-mediated TP53 polyubiquitination. The NCBI summary also notes that the protein may be one of the target molecules involved in mediating growth inhibition by interferon. These points make it of interest to researchers studying ribosome biology alongside the p53 pathway.
RPL23A is a 60S subunit component that binds a specific region of rRNA, making it relevant to studies of large subunit composition and protein synthesis.
RPL23A may promote p53/TP53 degradation, possibly by stimulating MDM2-mediated polyubiquitination, linking ribosomal proteins to p53 regulation.
The protein may be a target molecule involved in mediating growth inhibition by interferon, which makes it a candidate for interferon response studies.
The gene is co-transcribed with the U42A, U42B, U101A and U101B small nucleolar RNA genes, offering a model for host gene and snoRNA co-expression.
RPL23A is a component of the large (60S) ribosomal subunit and takes part in cellular protein synthesis. It binds a specific region of the 26S rRNA. It may also promote p53/TP53 degradation, possibly by stimulating MDM2-mediated TP53 polyubiquitination.
RPL23A is the HGNC symbol for ribosomal protein L23a. Aliases include L23A and uL23, and UniProt names the protein large ribosomal subunit protein uL23. It belongs to the universal uL23 family, described by NCBI as the L23P family of ribosomal proteins.
Mouse and rat both have an orthologue named Rpl23a, and the protein belongs to a universal ribosomal protein family. The human gene is co-transcribed with the U42A, U42B, U101A and U101B snoRNA genes, and has multiple processed pseudogenes. Check the datasheet of any product for its validated reactivity.
Other large subunit ribosomal proteins and ribosomal stalk proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P62750; product specifications from Assay Genie datasheets.