FAM3B
FAM3B (FAM3 metabolism regulating signalling molecule B, also known as PANDER) is a secreted protein of the FAM3 family. It is annotated as inducing apoptosis of alpha and beta cells and is linked to insulin secretion. Browse Assay Genie's current range of FAM3B research reagents below, or read on for the biology behind the target.
FAM3B is a secreted protein that induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Because those cells are the glucagon- and insulin-producing cells of the pancreatic islet, the protein is of interest to researchers studying how secreted factors influence islet cell survival. The NCBI Gene summary describes FAM3B as predicted to enable cytokine activity and as involved in insulin secretion, and it is reported to be located in extracellular exosomes.
The FAM3B gene encodes a protein that belongs to the FAM3 family, which also includes FAM3A, FAM3C and FAM3D. The mouse ortholog is Fam3b. A FAM3B protein assay is therefore usually a study of a secreted factor, so it can be measured outside the cell and not only in cell lysates.
The gene has had several names. Its HGNC name is FAM3 metabolism regulating signalling molecule B. Earlier names include family with sequence similarity 3 member B and chromosome 21 open reading frame 11. Aliases and previous symbols include PANDER, C21orf11, C21orf76, PRED44, ORF9, 2-21 and D21M16SJHU19e. The PANDER alias is the name most often met in the literature on this protein, and it is worth including when searching for FAM3B.
FAM3B is annotated as inducing apoptosis of alpha and beta cells, making it relevant to studies of islet cell survival.
The NCBI Gene summary lists FAM3B as involved in insulin secretion, so it features in work on secretory regulation.
FAM3B is predicted to enable cytokine activity, which places it among secreted signalling factors worth characterising.
FAM3B is reported to be located in extracellular exosomes, linking it to studies of secreted and vesicle-associated proteins.
FAM3B is a secreted protein that induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. It is also described as involved in insulin secretion and is predicted to enable cytokine activity.
Yes. FAM3B is also called PANDER, and has the aliases C21orf11, C21orf76, PRED44, ORF9, 2-21 and D21M16SJHU19e. Its earlier names were family with sequence similarity 3 member B and chromosome 21 open reading frame 11.
A mouse ortholog, Fam3b, is recorded for the human gene. FAM3B belongs to the FAM3 family, alongside FAM3A, FAM3C and FAM3D. Check the datasheet of any product for its validated reactivity.
Other FAM3 family members and further FAM-named proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P58499; product specifications from Assay Genie datasheets.