KDM6B
KDM6B (lysine demethylase 6B, also known as JMJD3 or KIAA0346) is a nuclear histone demethylase that removes methyl groups from lysine 27 of histone H3. It links chromatin state to development, inflammatory responses and gene regulation. Browse Assay Genie's current range of KDM6B research reagents below, or read on for the biology behind the target.
KDM6B is a lysine-specific demethylase that acts on histone H3. It specifically demethylates di- and trimethylated lysine 27 (H3K27me2 and H3K27me3). H3K27 trimethylation is a repressive epigenetic mark that controls chromatin organisation and gene silencing, so removing it plays a central role in the histone code. KDM6B can also demethylate non-histone proteins, including the retinoblastoma protein. Separately from its catalytic activity, it has a demethylase-independent role in chromatin remodelling. There it links T-box transcription factors to the SMARCA4-containing SWI/SNF remodelling complex, which shapes T-box-dependent gene expression.
The KDM6B gene encodes a protein of the lysine demethylase 6 family, which belongs to the UTX family. The protein is nuclear and carries two classical nuclear localisation signals at its N-terminus. Alternative splicing produces multiple transcript variants that encode distinct isoforms. The mouse ortholog is Kdm6b.
Functionally, KDM6B regulates HOX gene expression and so plays a central role in posterior development. It is also involved in the inflammatory response, where it takes part in macrophage differentiation by regulating gene expression. Through its demethylase activity it influences cellular differentiation and development, tumorigenesis, inflammatory diseases and neurodegenerative diseases. The protein was originally named jumonji domain containing 3 (JMJD3), and that name remains in wide use alongside the approved symbol.
KDM6B removes the repressive H3K27me2 and H3K27me3 marks, making it a key enzyme for studying chromatin organisation and gene silencing.
KDM6B regulates HOX gene expression and posterior development, and influences cellular differentiation more broadly.
KDM6B participates in macrophage differentiation during inflammation by regulating gene expression, linking histone demethylation to immune responses.
Through its demethylase activity, KDM6B influences tumorigenesis, inflammatory diseases and neurodegenerative diseases, and it can also act on retinoblastoma protein.
KDM6B is a histone demethylase that removes methyl groups from di- and trimethylated lysine 27 of histone H3, relieving a repressive mark. It regulates HOX gene expression, contributes to macrophage differentiation in inflammation, and can also demethylate retinoblastoma protein. Check the datasheet of any product for its validated reactivity.
KDM6B is also known as JMJD3 and KIAA0346. Earlier names include jumonji domain containing 3 and lysine (K)-specific demethylase 6B. Alternative splicing of the gene gives multiple transcript variants that encode distinct isoforms.
Yes. KDM6B acts as a link between T-box transcription factors and the SMARCA4-containing SWI/SNF chromatin remodelling complex. This regulates T-box-dependent gene expression without requiring its demethylase activity. The mouse ortholog is Kdm6b.
Other lysine demethylases involved in histone modification and epigenetic regulation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15054; product specifications from Assay Genie datasheets.