CDCP1
CDCP1 (CUB domain-containing protein 1, also known as CD318 or SIMA135) is a transmembrane protein with three extracellular CUB domains. It is a substrate of Src family kinases and is linked to the regulation of cell adhesion, migration and tumour invasion. Browse Assay Genie's current range of CDCP1 research reagents below, or read on for the biology behind the target.
CDCP1 is a transmembrane protein that carries three extracellular CUB domains and acts as a substrate for Src family kinases. Its activity is tied to tyrosine phosphorylation. Through this phosphorylation, CDCP1 is thought to take part in regulating cellular events involved in tumour invasion and metastasis. UniProt annotates it as possibly involved in cell adhesion and cell matrix association, and as possibly helping to set the balance between anchorage and migration, or between proliferation and differentiation, via its phosphorylation.
The CDCP1 gene encodes a protein found at the cell membrane, and UniProt also lists a secreted form. Alternative splicing of the CDCP1 gene produces multiple transcript variants. The protein belongs to the tetraspanin web, a membrane organisation that has been associated with tumour progression and metastasis. The mouse ortholog is Cdcp1.
CDCP1 is classed by HGNC within the CD molecules, which explains the alias CD318. The other alias, SIMA135, is also in use. UniProt notes that CDCP1 may be a novel marker for leukaemia diagnosis and for immature haematopoietic stem cell subsets. Researchers studying the CDCP1 protein therefore tend to focus on Src-dependent signalling, adhesion biology and tumour spread, and on its use as a cell-surface marker.
CDCP1 is regulated by tyrosine phosphorylation and is involved in cellular events underlying tumour invasion and metastasis.
CDCP1 is a substrate of Src family kinases, making it a useful node for studying phosphorylation-dependent signalling.
CDCP1 may influence cell adhesion, matrix association and the balance between anchorage and migration through its phosphorylation.
CDCP1 may serve as a marker for leukaemia diagnosis and for immature haematopoietic stem cell subsets.
CDCP1 is a transmembrane protein and Src family kinase substrate. It is implicated in tyrosine phosphorylation-dependent regulation of events in tumour invasion and metastasis. UniProt also suggests roles in cell adhesion, cell matrix association, and the choice between anchorage and migration or between proliferation and differentiation.
CDCP1 stands for CUB domain containing protein 1. It is also called CD318 and SIMA135. The CD318 name reflects its place among the CD molecules. Alternative splicing of the gene gives multiple transcript variants, so check the datasheet of any product for its validated reactivity.
A mouse ortholog, Cdcp1, is recorded. CDCP1 is associated with tumour invasion and metastasis and is described as part of the tetraspanin web involved in tumour progression. It may also be a marker for leukaemia and immature haematopoietic stem cells.
Other CD molecules, Src family kinases and tumour progression markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H5V8; product specifications from Assay Genie datasheets.