FES
FES (FES proto-oncogene, tyrosine kinase, also known as FPS) is a non-receptor tyrosine kinase that acts downstream of cell surface receptors. It helps regulate the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Browse Assay Genie's current range of FES research reagents below, or read on for the biology behind the target.
FES is a tyrosine-protein kinase that acts downstream of cell surface receptors. It contributes to the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. In mast cells it functions in signalling from the high affinity immunoglobulin epsilon receptor (FCER1) and from the mast/stem cell growth factor receptor KIT, and it plays a role in regulating mast cell degranulation. It also takes part in cell differentiation, promoting neurite outgrowth in response to NGF signalling, and in cell scattering and migration following HGF-induced activation of EZR.
Reported substrates of the kinase include BCR, whose kinase activity FES down-regulates, as well as HCLS1/HS1, PECAM1, STAT3 and TRIM28. The protein belongs to the protein kinase superfamily, Tyr protein kinase family, Fes/fps subfamily. HGNC classifies it within SH2 domain containing, F-BAR domain containing and Fes family tyrosine kinases. UniProt records it in the cytosol, cytoskeleton, cell membrane, cytoplasmic vesicles, Golgi apparatus and focal adhesions. A mouse ortholog, Fes, is annotated.
The FES gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capability, which explains the earlier names feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog. Its tyrosine kinase activity is required for maintaining cellular transformation. Its chromosomal location has been linked to a translocation identified in patients with acute promyelocytic leukaemia, and it is also involved in normal haematopoiesis and in growth factor and cytokine receptor signalling. Alternative splicing produces multiple variants encoding different isoforms.
FES is the cellular counterpart of a viral transforming protein, and its kinase activity is needed to maintain cellular transformation.
The gene is involved in normal haematopoiesis and lies at a locus linked to a translocation in acute promyelocytic leukaemia.
FES acts downstream of FCER1 and KIT and helps regulate mast cell degranulation.
FES regulates actin and microtubule organisation, cell attachment, spreading, and HGF-induced cell scattering and migration.
FES is a non-receptor tyrosine kinase that acts downstream of cell surface receptors. It regulates the actin cytoskeleton, microtubule assembly, cell attachment and spreading, contributes to FCER1 and KIT signalling in mast cells, and phosphorylates substrates including BCR, HCLS1/HS1, PECAM1, STAT3 and TRIM28.
FES is also known as FPS, and the protein is named Tyrosine-protein kinase Fes/Fps. Earlier names refer to the feline sarcoma and Fujinami avian sarcoma viral oncogene homologs (v-fes and v-fps). Alternative splicing of the gene gives multiple variants that encode different isoforms.
The FES locus has been linked to a translocation found in patients with acute promyelocytic leukaemia, and its kinase activity is required to maintain transformation. A mouse ortholog, Fes, is annotated; check the datasheet of any product for its validated reactivity.
Substrates, upstream receptors and signalling partners of FES, including other proteins in mast cell and cytoskeletal signalling pathways.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P07332; product specifications from Assay Genie datasheets.