FCRL3

FCRL3

Target · Fc receptor-like protein

FCRL3 Fc receptor like 3 · CD307c

FCRL3 (Fc receptor like 3, also known as FCRH3, IRTA3, IFGP3, CD307c and MAIA) is a member of the immunoglobulin receptor superfamily. It regulates B-cell and T-cell responses and takes part in sperm-egg adhesion and fusion. Browse Assay Genie's current range of FCRL3 research reagents below, or read on for the biology behind the target.

Cell membrane, microvilliImmunoglobulin receptor superfamilyHuman-specific oocyte epitope
View FCRL3 productsAbout FCRL3
734 aa
Protein length
~81 kDa
Molecular weight
1q23.1
Gene locus
Ig superfamily</stat4_value> <parameter name="stat4_label">Protein family</stat4_label> <parameter name="about_paragraphs">["FCRL3 is a cell-surface immunoregulatory receptor with a dual role in B cells. It promotes TLR9-induced B-cell proliferation, activation and survival, and enhances NF-kappa-B and MAPK signalling in TLR9-stimulated B cells. At the same time it inhibits antibody production and suppresses plasma cell differentiation. It also has inhibitory potential on B-cell receptor (BCR) signalling, possibly through association with SH2 domain-containing phosphatases. Through this route it limits cell tyrosine phosphorylation, calcium mobilisation and activation-induced cell death triggered by the BCR.", "The role of FCRL3 extends to T cells. Regulatory T cells that express FCRL3 show a memory phenotype, respond poorly to antigenic stimulation in the presence of IL-2, and have a reduced capacity to suppress effector T-cell proliferation. In reproductive biology, FCRL3 acts as a human-specific epitope on the oocyte surface (oolemma). It interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as the IZUMO1 receptor, which permits species-specific gamete fusion.", "The <em>FCRL3</em> gene encodes one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The protein is found at the cell membrane, including the microvillus membrane, and carries immunoreceptor tyrosine-based activation and inhibitory motifs in its cytoplasmic domain. Alternative splicing gives multiple transcript variants. Mutations in the gene have been associated with rheumatoid arthritis, autoimmune thyroid disease and systemic lupus erythematosus. HGNC lists it among the CD molecules, immunoglobulin-like domain-containing proteins and Fc receptors, and its previous name was Fc receptor-like 3."]
Protein family
Target information

What is FCRL3 (fc receptor like 3)?

B-cell signalling

FCRL3 enhances TLR9-driven NF-kappa-B and MAPK signalling while restraining BCR-mediated phosphorylation and calcium mobilisation.

Regulatory T-cell biology

FCRL3-expressing regulatory T cells have a memory phenotype and a reduced capacity to suppress effector T-cell proliferation.

Autoimmune disease research

Mutations in FCRL3 have been associated with rheumatoid arthritis, autoimmune thyroid disease and systemic lupus erythematosus.

Fertilisation and gamete fusion

FCRL3 on the oolemma interacts with IZUMO1 and replaces IZUMO1R/JUNO as its receptor, permitting species-specific sperm-egg fusion.

Background

FCRL3 frequently asked questions

What does FCRL3 do?

FCRL3 is a membrane receptor that promotes TLR9-induced B-cell proliferation, activation and survival, yet inhibits antibody production and plasma cell differentiation. It also dampens BCR signalling, modulates regulatory T-cell function and acts as an IZUMO1 receptor on human oocytes during sperm-egg fusion.

What other names does FCRL3 go by?

FCRL3 is also known as FCRH3, IRTA3, IFGP3, SPAP2 (with variants SPAP2a to SPAP2e), CD307c and MAIA. Its previous name was Fc receptor-like 3. Alternative splicing of the gene produces multiple transcript variants, so literature and product descriptions may use different names.

Is FCRL3 linked to disease?

NCBI Gene reports that mutations in FCRL3 have been associated with rheumatoid arthritis, autoimmune thyroid disease and systemic lupus erythematosus. The protein is also described as a human-specific oocyte epitope, so check the datasheet of any product for its validated reactivity.

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Related targets

Other Fc receptor-like family members that cluster with FCRL3 on chromosome 1 and regulate immune cell function.

FCRL1 · Fc receptor like 1 FCRL5 · Fc receptor like 5 All targets A–Z

Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96P31; product specifications from Assay Genie datasheets.

FCRL3 Product listing