CEBPD
CEBPD (CCAAT enhancer binding protein delta, also known as C/EBP-delta, NF-IL6-beta, CRP3 and CELF) is a nuclear bZIP transcription factor of the C/EBP subfamily. It regulates genes involved in immune and inflammatory responses. Browse Assay Genie's current range of CEBPD research reagents below, or read on for the biology behind the target.
CEBPD is a transcription activator that recognises two different DNA motifs: the CCAAT homology found in many promoters and the enhanced core homology found in many enhancers. It is an important transcription factor controlling the expression of genes involved in immune and inflammatory responses. It enhances transcription of IL6, both on its own and as a heterodimer with CEBPB.
The CEBPD gene is intronless and encodes a bZIP transcription factor that can bind DNA as a homodimer at certain regulatory regions. The protein can also form heterodimers with the related family member CEBP-alpha. According to the NCBI Gene summary, it may also take part in regulating genes associated with the activation and/or differentiation of macrophages. UniProt places the protein in the nucleus and assigns it to the bZIP family, C/EBP subfamily. Mouse and rat both carry a Cebpd ortholog.
The protein is known by several names, including C/EBP-delta, NF-IL6-beta, CRP3 and CELF, and HGNC groups it with the CCAAT/enhancer binding proteins. The cytogenetic location of the locus has been reported as both 8p11 and 8q11. Researchers studying the CEBPD gene commonly examine it alongside other C/EBP members because of the homo- and heterodimer combinations these factors form.
CEBPD regulates genes involved in immune and inflammatory responses, making it a focus for studies of transcriptional control of inflammation.
CEBPD enhances IL6 transcription alone and as a heterodimer with CEBPB, providing a model for cooperative control of cytokine genes.
The protein may help regulate genes linked to macrophage activation and differentiation, relevant to studies of myeloid cell function.
CEBPD binds DNA as a homodimer and forms heterodimers with CEBP-alpha, supporting work on how bZIP factor combinations shape gene expression.
CEBPD is a nuclear transcription activator that recognises the CCAAT homology found in many promoters and the enhanced core homology found in many enhancers. It regulates genes involved in immune and inflammatory responses and enhances IL6 transcription, alone or as a heterodimer with CEBPB.
CEBPD stands for CCAAT enhancer binding protein delta. Aliases include C/EBP-delta, NF-IL6-beta, CRP3 and CELF. Older HGNC names are written as CCAAT/enhancer binding protein (C/EBP), delta. UniProt lists the protein as CCAAT/enhancer-binding protein delta. Check the datasheet of any product for its validated reactivity.
Yes. Mouse and rat each have an ortholog named Cebpd. The human protein belongs to the bZIP family, C/EBP subfamily. The gene is intronless, and its locus has been reported as both 8p11 and 8q11. Check the datasheet of any product for its validated reactivity.
Other C/EBP family members, their heterodimer partners and inflammatory cytokine targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49716; product specifications from Assay Genie datasheets.