GATA6
GATA6 (GATA binding protein 6) is a nuclear zinc finger transcription factor that activates gene expression during vertebrate development. It contributes to the regulation of cellular differentiation and organogenesis, and was previously named GATA-binding protein 6. Browse Assay Genie's current range of GATA6 research reagents below, or read on for the biology behind the target.
GATA6 is a transcriptional activator that regulates the expression of tissue-specific genes. UniProt annotates it as regulating SEMA3C and PLXNA2, and as being involved in gene regulation specifically in the gastric epithelium, where it may regulate genes that protect epithelial cells from bacterial infection. In the heart, GATA6 is involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression and binds BMP response element (BMPRE) DNA sequences within cardiac activating regions.
In human skin, GATA6 controls several processes that contribute to homeostasis of the upper pilosebaceous unit. It triggers ductal and sebaceous differentiation, limits cell proliferation and lipid production to prevent hyperseborrhoea, and mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. It also contributes to immune regulation of sebocytes and antimicrobial responses by modulating anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4 and IFNG. GATA6 activates TGFB1 signalling, which controls interfollicular epidermis fate.
The GATA6 gene belongs to a small family of zinc finger transcription factors, classified by HGNC in the GATA zinc finger domain containing group, which regulate cellular differentiation and organogenesis during vertebrate development. According to the NCBI Gene summary, it is expressed during early embryogenesis and localises to endo- and mesodermally derived cells later on, playing an important role in gut, lung and heart development. Mutations in this gene are associated with several congenital defects. Mouse and rat orthologs are both named Gata6.
GATA6 is expressed in early embryogenesis and in endo- and mesodermally derived cells, making it a key factor for studying gut, lung and heart development.
GATA6 is involved in BMP-mediated cardiac-specific gene expression and binds BMP response elements within cardiac activating regions.
GATA6 controls ductal and sebaceous differentiation and limits lipid production in the human pilosebaceous unit, and mediates retinoic acid effects on sebocytes.
Mutations in the GATA6 gene are associated with several congenital defects, so the protein is relevant to studies of developmental disorders.
GATA6 is a transcriptional activator in the nucleus. It regulates gene expression in the gastric epithelium, drives BMP-mediated cardiac gene expression, and controls differentiation and lipid production in human sebocytes. It also modulates immune genes such as IL10, IL6, TLR2, TLR4 and IFNG, and activates TGFB1 signalling.
HGNC lists the approved name as GATA binding protein 6, with the previous name GATA-binding protein 6. UniProt names the protein Transcription factor GATA-6. No other aliases or previous symbols are recorded, and the gene sits in the GATA zinc finger domain containing group.
GATA6 has orthologs named Gata6 in both mouse and rat, so it can be studied in rodent models; check the datasheet of any product for its validated reactivity. NCBI Gene reports that mutations in the human gene are associated with several congenital defects.
Other GATA family transcription factors that regulate differentiation and organogenesis, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92908; product specifications from Assay Genie datasheets.