IGFBP-2
IGFBP-2 (insulin-like growth factor-binding protein 2, also known as IBP2) is a secreted, multifunctional protein that controls how much IGF-I and IGF-II reaches their receptors. Through this and other interactions it influences cell proliferation, differentiation, apoptosis and migration. Browse Assay Genie's current range of IGFBP-2 research reagents below, or read on for the biology behind the target.
IGFBP-2 plays a critical role in regulating the availability of IGFs, such as IGF1 and IGF2, to their receptors. In doing so it shapes IGF-mediated cellular processes including proliferation, differentiation and apoptosis, and its effects are cell-type specific. It works together with receptor protein tyrosine phosphatase beta (PTPRB) and the IGF1 receptor to regulate IGF1-mediated signalling, stimulating the phosphorylation of PTEN, which inactivates it and leads to AKT1 activation.
IGFBP-2 also acts beyond IGF sequestration. It promotes cell migration by interacting with integrin alpha5 (ITGA5) through an RGD motif, and its interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. After mitochondrial damage, it facilitates apoptosis of podocytes together with ITGA5, and activates phosphorylation of focal adhesion kinase (FAK), which mediates mitochondrial injury.
The IGFBP2 gene encodes one of six similar proteins that bind IGF-I and IGF-II. The protein can be secreted into the bloodstream, where it binds both ligands with high affinity, or it can remain intracellular and interact with many different ligands. Several transcript variants exist: one encodes a secreted isoform and the others encode nonsecreted isoforms. High expression of IGFBP-2 promotes the growth of several types of tumour and may be predictive of patient recovery. Earlier HGNC names refer to it as the 36 kD insulin-like growth factor binding protein 2, and the mouse and rat orthologs are both designated Igfbp2.
IGFBP-2 regulates IGF-I and IGF-II access to their receptors, making it a key component for studying IGF-mediated proliferation, differentiation and apoptosis.
High IGFBP-2 expression promotes the growth of several tumour types and may predict patient recovery, so it is studied as a tumour-associated factor.
IGFBP-2 works with PTPRB and the IGF1 receptor to drive PTEN phosphorylation and AKT1 activation, linking it to IGF1-mediated signal transduction.
Through an RGD motif, IGFBP-2 engages integrin alpha5 to promote migration and endothelial progenitor cell adhesion to endothelial cells.
IGFBP-2 binds IGF-I and IGF-II and regulates their availability to receptors, thereby influencing IGF-mediated proliferation, differentiation and apoptosis in a cell-type specific manner. It also promotes cell migration through integrin alpha5 and supports IGF1-mediated signalling via PTEN inactivation and AKT1 activation.
IGFBP-2 is encoded by the IGFBP2 gene and is also called IBP2. Older HGNC names describe it as the 36 kD insulin-like growth factor binding protein 2. Several transcript variants exist: one encodes a secreted isoform, while the others encode nonsecreted isoforms.
High IGFBP-2 expression promotes the growth of several tumour types and may be predictive of the chances of patient recovery. Orthologs named Igfbp2 exist in both mouse and rat; check the datasheet of any product for its validated reactivity.
Other members of the insulin-like growth factor binding protein family, which share the ability to bind IGF-I and IGF-II.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P18065; product specifications from Assay Genie datasheets.