PLA2G12B
PLA2G12B (phospholipase A2 group XIIB, also known as PLA2G13) is a secreted member of the phospholipase A2 family that has lost catalytic activity. It is linked to the regulation of HNF4alpha-induced hepatitis C virus infectivity and is down-regulated in various tumours. Browse Assay Genie's current range of PLA2G12B research reagents below, or read on for the biology behind the target.
PLA2G12B belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. Unlike most of its relatives, this family member has altered phospholipid-binding properties and is catalytically inactive, so it is not expected to act as a lipid-hydrolysing enzyme. UniProt describes its function as not known and notes that it does not appear to have catalytic activity.
The PLA2G12B protein is secreted. According to the NCBI Gene summary, together with microsomal triglyceride transfer protein it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. Alternative splicing of the PLA2G12B gene results in multiple transcript variants. The protein is classed by HGNC in the phospholipases gene group, and the mouse ortholog is Pla2g12b.
Expression of PLA2G12B is down-regulated in various tumours, which suggests it may function as a negative regulator of tumour progression. The gene was previously named phospholipase A2, group XIII, and carries the earlier symbol PLA2G13; the current name, phospholipase A2 group XIIB, reflects its place in the PLA2 classification. Researchers studying this protein often compare it with catalytically active PLA2 family members to understand how loss of enzymatic activity relates to its biological role.
PLA2G12B acts with microsomal triglyceride transfer protein to regulate HNF4alpha-induced hepatitis C virus infectivity.
Its expression is down-regulated in various tumours, suggesting a role as a negative regulator of tumour progression.
As a catalytically inactive member with altered phospholipid binding, it offers a contrast to active PLA2 enzymes.
PLA2G12B is a secreted protein whose function remains incompletely defined, making it a subject for extracellular lipid-related studies.
PLA2G12B is a secreted phospholipase A2 family member that lacks catalytic activity. UniProt lists its function as not known, while NCBI reports that, together with microsomal triglyceride transfer protein, it regulates HNF4alpha-induced hepatitis C virus infectivity.
The HGNC name is phospholipase A2 group XIIB, and UniProt calls the protein group XIIB secretory phospholipase A2-like protein. PLA2G13 is an earlier symbol, from the previous name phospholipase A2, group XIII. Alternative splicing produces multiple transcript variants.
Expression of PLA2G12B is down-regulated in various tumours, suggesting a negative regulatory role in tumour progression. A mouse ortholog, Pla2g12b, exists; check the datasheet of any product for its validated reactivity.
Other phospholipase A2 family members and related lipid-modifying enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BX93; product specifications from Assay Genie datasheets.