RAB34
RAB34 (RAB34, member RAS oncogene family; also known as RAB39 and RAH) is a small GTPase of the RAB family that acts in protein transport. It is a Golgi-bound member of the secretory pathway, and an alternatively spliced transcript encodes the distinct nucleolar protein NARR. Browse Assay Genie's current range of RAB34 research reagents below, or read on for the biology behind the target.
RAB34 belongs to the RAB family of small GTPases, which are involved in protein transport. This family member is a Golgi-bound component of the secretory pathway. It is involved in the repositioning of lysosomes and in the activation of macropinocytosis, which makes the RAB34 protein a useful subject for studies of intracellular trafficking and membrane dynamics.
The RAB34 gene is assigned by HGNC to the group of RAB, member RAS oncogene GTPases. Alternative splicing of the gene produces multiple transcript variants. One of these, read in a different reading frame, yields the nine-amino acid residue-repeats protein, abbreviated NARR. NARR is described as a functionally distinct nucleolar protein, and UniProt lists it as the isoform NARR, with nuclear and nucleolar localisation. This is why a single gene can be relevant to both Golgi-associated trafficking and nucleolar biology.
The protein has also been indexed under the aliases RAB39, RAH and NARR. Mouse and rat each have an orthologue named Rab34, so the gene can be studied in common rodent models. Researchers working with a RAB34 antibody or RAB34 ELISA kit should note that the canonical GTPase and the NARR product arise from the same locus but differ in function and location, so the isoform of interest matters when designing and interpreting experiments.
RAB34 is a Golgi-bound member of the secretory pathway, making it relevant to studies of protein transport.
The protein is involved in the repositioning of lysosomes, a process of interest in intracellular organelle organisation.
RAB34 is involved in the activation of macropinocytosis, linking this GTPase to membrane uptake mechanisms.
Alternative splicing yields NARR, a functionally distinct nucleolar protein from a different reading frame, enabling isoform-specific investigation.
RAB34 is a small GTPase of the RAB family, which are involved in protein transport. It is a Golgi-bound member of the secretory pathway and is involved in the repositioning of lysosomes and the activation of macropinocytosis.
RAB34 is also known as RAB39 and RAH. Alternative splicing gives multiple transcript variants. One variant produces the nine-amino acid residue-repeats protein, NARR, a nucleolar protein translated from a different reading frame and functionally distinct from the GTPase.
Yes. Both mouse and rat have an orthologue named Rab34, so rodent models can be used to study the gene. Check the datasheet of any product for its validated reactivity before choosing reagents for a given species.
Other RAB family GTPases involved in membrane trafficking and vesicle transport.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P0DI83; product specifications from Assay Genie datasheets.