RCBTB2
RCBTB2, or RCC1 and BTB domain containing protein 2, is a protein related to the regulator of chromosome condensation (RCC) and carrying two C-terminal BTB/POZ domains. It was previously known as CHC1L (chromosome condensation 1-like) and may act as a guanine nucleotide exchange factor. Browse Assay Genie's current range of RCBTB2 research reagents below, or read on for the biology behind the target.
RCBTB2 is a protein related to the regulator of chromosome condensation (RCC). According to the NCBI Gene summary, it may act as a guanine nucleotide exchange factor, although this role is described as possible rather than established. Its architecture combines a domain relationship with RCC1 and two C-terminal BTB/POZ domains, which places it in the HGNC gene group of BTB domain containing proteins. UniProt annotates the protein as localised to the acrosome, a secretory vesicle within the cytoplasm.
The RCBTB2 gene encodes a protein of 551 amino acids and sits at 13q14.2 in the human genome. Alternative splicing of the gene produces multiple transcript variants, and a pseudogene of the gene is found on chromosome 10. Orthologues of the gene are annotated in both mouse and rat, each named Rcbtb2, which allows comparative work in rodent models.
The gene symbol and names reflect its relationship to RCC1. The previous symbol CHC1L stood for chromosome condensation 1-like, and an earlier full name was regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. Current HGNC nomenclature uses RCC1 and BTB domain containing protein 2. In terms of disease relevance, the RCBTB2 gene is observed to be lost or underexpressed in prostate cancers, which has made it a candidate of interest for studies of tumour suppression and gene regulation in that tissue. Researchers studying RCBTB2 may look for the RCBTB2 protein, its transcripts or its expression changes, for example with an RCBTB2 antibody or an RCBTB2 ELISA kit where such tools exist.
RCBTB2 is observed to be lost or underexpressed in prostate cancers, making its expression a point of interest in tumour studies.
The protein may act as a guanine nucleotide exchange factor, prompting investigation of its possible role in small GTPase regulation.
RCBTB2 carries two C-terminal BTB/POZ domains and belongs to the BTB domain containing gene group.
UniProt places RCBTB2 in the acrosome, a secretory vesicle, which makes it relevant to studies of that compartment.
The NCBI Gene summary states that RCBTB2 may act as a guanine nucleotide exchange factor. The protein is related to the regulator of chromosome condensation and has two C-terminal BTB/POZ domains. Its precise function has not been firmly defined in the source data.
RCBTB2 was formerly called CHC1L, short for chromosome condensation 1-like. Its HGNC full name is RCC1 and BTB domain containing protein 2. Alternative splicing of the gene gives rise to multiple transcript variants, so more than one transcript can arise from the locus.
The RCBTB2 gene is observed to be lost or underexpressed in prostate cancers. Orthologues named Rcbtb2 are annotated in mouse and rat. Check the datasheet of any product for its validated reactivity.
Other RCC1-related and BTB domain proteins, plus tumour suppressor markers studied alongside RCBTB2.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95199; product specifications from Assay Genie datasheets.