SCG3
SCG3 (secretogranin III, also known as SgIII and FLJ90833) is a member of the granin family of neuroendocrine secretory proteins. It regulates the biogenesis of secretory granules and acts as a sorting receptor for intragranular proteins such as chromogranin A. Browse Assay Genie's current range of SCG3 research reagents below, or read on for the biology behind the target.
SCG3 is a member of the granin protein family and regulates the biogenesis of secretory granules. It acts as a sorting receptor for intragranular proteins, including chromogranin A (CHGA), directing them into the regulated secretory pathway. UniProt also notes that SCG3 may play a role in angiogenesis, where it promotes endothelial proliferation, migration and tube formation through the MEK/ERK signalling pathway.
The SCG3 gene encodes secretogranin-3, a protein annotated to the cytoplasmic secretory vesicle, the secretory vesicle membrane and the extracellular space. NCBI Gene describes it as a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins, and two transcript variants encoding different isoforms have been reported. Mouse and rat both have an ortholog named Scg3, which allows the protein to be studied in common rodent models.
Granins as a group may serve as precursors for biologically active peptides, and some act as helper proteins in the sorting and proteolytic processing of prohormones. For SCG3, NCBI Gene states that its precise function is unknown, while UniProt records the granule-sorting and angiogenesis roles above. HGNC places the gene in the Granins group, and the protein is also referred to as SgIII. Researchers studying neuroendocrine secretion, granule biogenesis or endothelial signalling may use an SCG3 antibody, SCG3 ELISA kit or recombinant SCG3 protein to examine expression and function.
SCG3 regulates the biogenesis of secretory granules, making it a relevant protein for studying how regulated secretory vesicles form.
SCG3 acts as a sorting receptor for intragranular proteins including chromogranin A, supporting work on cargo selection into granules.
As a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins, SCG3 is a marker for studying secretory pathways.
SCG3 may promote endothelial proliferation, migration and tube formation through the MEK/ERK signalling pathway.
SCG3 is a granin family protein that regulates the biogenesis of secretory granules and acts as a sorting receptor for intragranular proteins such as chromogranin A. It may also contribute to angiogenesis by promoting endothelial proliferation, migration and tube formation through MEK/ERK signalling.
SCG3 stands for secretogranin III, and the protein is called secretogranin-3 in UniProt. Aliases include SgIII and FLJ90833. NCBI Gene reports two transcript variants that encode different isoforms, so check which isoform a reagent is intended to detect.
Yes, both mouse and rat have an ortholog named Scg3. SCG3 belongs to the granin family, a group of neuroendocrine secretory proteins. Check the datasheet of any product for its validated reactivity before using it in a given species.
Other granins, secretogranins and secretory-pathway proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WXD2; product specifications from Assay Genie datasheets.