EMP3
EMP3 (epithelial membrane protein 3, also known as YMP) is a membrane protein of the PMP-22/EMP/MP20 family. It is thought to be involved in cell proliferation and cell-cell interactions, and has been proposed to act as a tumour suppressor. Browse Assay Genie's current range of EMP3 research reagents below, or read on for the biology behind the target.
EMP3 is annotated as probably being involved in cell proliferation and cell-cell interactions. The NCBI Gene summary adds that it is thought to function as a tumour suppressor. The precise molecular mechanism is not described in the source annotation, so the protein is best understood through these proposed roles in growth control and cell contact.
The EMP3 protein belongs to the PMP-22/EMP/MP20 family. It contains four transmembrane domains and two N-linked glycosylation sites, and it is located in the membrane. Alternative splicing of the EMP3 gene results in multiple transcript variants. Orthologues are found in mouse and rat, both named Emp3, which allows the protein to be studied in common model systems.
The approved HGNC name is epithelial membrane protein 3 (MAM blood group), and the gene is classed in the HGNC group of blood group antigens. YMP is a recognised alias. Within the same family, EMP1 is a related epithelial membrane protein that is often considered alongside EMP3 when studying this group of proteins.
EMP3 is thought to be involved in cell proliferation, making it a candidate for studies of growth regulation.
The protein is probably involved in cell-cell interactions, relevant to work on membrane proteins at cell contacts.
EMP3 is thought to function as a tumour suppressor, so it is investigated in cancer biology.
As a four-transmembrane-domain protein of this family, EMP3 is useful for comparative work across related membrane proteins.
EMP3 is probably involved in cell proliferation and cell-cell interactions. The NCBI Gene summary also reports that it is thought to function as a tumour suppressor. The detailed mechanism is not defined in the source annotation, and the protein is located in the membrane.
EMP3 is the approved symbol for epithelial membrane protein 3 (MAM blood group), and YMP is a recognised alias. Alternative splicing of the EMP3 gene results in multiple transcript variants, so researchers should consider which transcript or protein form is relevant to their work.
Yes, orthologues of human EMP3 are annotated in mouse and rat, both named Emp3. The protein belongs to the PMP-22/EMP/MP20 family. Check the datasheet of any product for its validated reactivity.
Other members of the epithelial membrane protein group and related membrane proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P54852; product specifications from Assay Genie datasheets.