ANXA7
ANXA7 (annexin A7, also known as ANX7 and annexin VII) is a calcium- and phospholipid-binding protein of the annexin family. It promotes membrane fusion and is involved in exocytosis. Browse Assay Genie's current range of ANXA7 research reagents below, or read on for the biology behind the target.
ANXA7 is a calcium/phospholipid-binding protein that promotes membrane fusion and is involved in exocytosis. As a member of the annexin family of calcium-dependent phospholipid-binding proteins, it associates with membranes in a calcium-dependent manner. Structural analysis suggests that annexin A7 is a membrane-binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.
The ANXA7 gene contains 14 exons. An alternatively spliced cassette exon gives rise to two mRNA transcripts of 2.0 and 2.4 kb, which are predicted to encode two protein isoforms that differ in their N-terminal domain. This splicing event is tissue specific: the transcript containing the cassette exon is prevalent in brain, heart and skeletal muscle. The two transcripts also differ in their 3' non-coding regions through the use of two alternative poly(A) signals.
The ANXA7 protein has a molecular weight of approximately 51 kDa. It combines a unique, highly hydrophobic N-terminal domain of 167 amino acids with a conserved C-terminal region of 299 amino acids, which is composed of alternating hydrophobic and hydrophilic segments. HGNC places the gene in the annexins group, and the mouse ortholog is Anxa7. Researchers studying calcium signalling, membrane dynamics and exocytosis use ANXA7 as a reference point within the wider annexin family.
ANXA7 promotes membrane fusion, making it a relevant target for work on how calcium-dependent lipid-binding proteins remodel membranes.
Annexin A7 is involved in exocytosis, so it is studied in the context of calcium-regulated vesicle and secretory processes.
Structural analysis points to voltage-sensitive calcium channel activity and ion selectivity, supporting investigation of annexin-mediated calcium handling.
As a calcium-dependent phospholipid-binding annexin, ANXA7 is used in comparative work across family members and their tissue-specific isoforms.
ANXA7 is a calcium/phospholipid-binding protein that promotes membrane fusion and is involved in exocytosis. Structural analysis also suggests voltage-sensitive calcium channel activity and ion selectivity, consistent with a membrane-binding protein of diverse properties.
ANXA7 is also called ANX7 and annexin VII. An alternatively spliced cassette exon yields two transcripts predicted to encode two isoforms that differ in their N-terminal domain. The cassette-exon transcript is prevalent in brain, heart and skeletal muscle.
Yes. The mouse ortholog is Anxa7, and the protein belongs to the conserved annexin family of calcium-dependent phospholipid-binding proteins. Check the datasheet of any product for its validated reactivity.
Other annexin family calcium-dependent phospholipid-binding proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P20073; product specifications from Assay Genie datasheets.