CTSH
CTSH (cathepsin H) is a lysosomal cysteine proteinase of the peptidase C1 family that contributes to the overall degradation of proteins in lysosomes. It is also known by the aliases ACC-4, ACC-5 and CPSB, and is produced as the precursor pro-cathepsin H. Browse Assay Genie's current range of CTSH research reagents below, or read on for the biology behind the target.
CTSH is a lysosomal cysteine proteinase that is important in the overall degradation of lysosomal proteins. It belongs to the peptidase C1 protein family and has a dual activity profile: it can act both as an aminopeptidase and as an endopeptidase. This combination allows it to contribute to protein turnover within the lysosome.
The CTSH gene encodes a single protein precursor, pro-cathepsin H, from which both chains of the mature enzyme are produced. The mature protein is a dimer of disulfide-linked heavy and light chains. Alternate splicing of the gene results in multiple transcript variants that encode different isoforms. Researchers working with the CTSH protein therefore need to consider the precursor, the processed chains and the isoforms when designing experiments.
HGNC classifies cathepsin H within the cathepsins, the minor histocompatibility antigens and the cysteine endopeptidases gene groups. Earlier symbols and aliases include ACC-4, ACC-5, ACC4, ACC5 and CPSB. Mouse and rat both have a Ctsh ortholog. In terms of disease relevance, increased expression of the CTSH gene has been correlated with malignant progression of prostate tumours, which makes it of interest in cancer biology alongside its role in lysosomal protein degradation.
CTSH is important in the overall degradation of proteins within lysosomes, making it a relevant protease for studying lysosomal function.
As a peptidase C1 family member acting as both aminopeptidase and endopeptidase, cathepsin H is a useful model for studying cysteine proteinase activity.
Increased CTSH expression has been correlated with malignant progression of prostate tumours, supporting its study in tumour biology.
A single precursor yields disulfide-linked heavy and light chains, and alternate splicing produces multiple isoforms, offering questions in processing and expression.
CTSH is a lysosomal cysteine proteinase that is important in the overall degradation of proteins in lysosomes. It belongs to the peptidase C1 family and can act both as an aminopeptidase and as an endopeptidase.
CTSH is cathepsin H, also called ACC-4, ACC-5, ACC4, ACC5 and CPSB. It is made as pro-cathepsin H, and the mature enzyme is a dimer of disulfide-linked heavy and light chains. Alternate splicing gives multiple isoforms.
Increased CTSH expression has been correlated with malignant progression of prostate tumours. Mouse and rat each have a Ctsh ortholog, so rodent models can be used; check the datasheet of any product for its validated reactivity.
Other cathepsins and lysosomal proteases that are studied alongside cathepsin H.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P09668; product specifications from Assay Genie datasheets.