SYNCRIP
SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein, also known as hnRNP-Q, HNRNPQ, NSAP1 and GRY-RBP) is a heterogeneous nuclear ribonucleoprotein implicated in mRNA processing. It takes part in mRNA stability, RNA editing and translational control complexes. Browse Assay Genie's current range of SYNCRIP research reagents below, or read on for the biology behind the target.
SYNCRIP is a heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. hnRNPs are RNA-binding proteins that complex with heterogeneous nuclear RNA and regulate alternative splicing, polyadenylation and other aspects of mRNA metabolism and transport. SYNCRIP interacts in vitro preferentially with poly(A) and poly(U) RNA sequences, and its isoforms 1, 2 and 3 associate in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes.
The protein acts in several defined complexes. It is a component of the CRD-mediated complex that promotes MYC mRNA stability, and works with other RNA-binding proteins in the cytoplasmic deadenylation, translation and decay interplay of FOS mRNA, mediated by the major coding-region determinant of instability (mCRD) domain. Isoform 1 binds AU-rich sequences of apoB mRNA and is part of the APOB mRNA editosome, where it may modulate C to U editing by binding A1CF, APOBEC1 or the RNA itself. SYNCRIP may also be involved in translationally coupled mRNA turnover. Isoform 3 may contribute to cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.
SYNCRIP is also a component of the GAIT (gamma interferon-activated inhibitor of translation) complex. After interferon-gamma activation, the complex binds stem loop-containing GAIT elements in the 3'-UTR of inflammatory mRNAs, such as ceruloplasmin, and suppresses their translation, although SYNCRIP does not appear to be essential for GAIT function. NCBI Gene notes an association with the survival of motor neurons (SMN) complex, and alternatively spliced transcript variants encode multiple isoforms. UniProt places the protein in the cytoplasm, microsomes and endoplasmic reticulum, and in the nucleus and nucleoplasm. Mouse and rat each have a Syncrip ortholog, and HGNC groups the human gene with RNA binding motif containing proteins and hnRNPs.
SYNCRIP is a component of the CRD-mediated complex that promotes MYC mRNA stability and is implicated in FOS mRNA decay.
Isoform 1 is part of the APOB mRNA editosome and may modulate C to U editing of APOB mRNA.
As a GAIT complex component, SYNCRIP is linked to interferon-gamma-induced, transcript-selective translation inhibition of inflammatory mRNAs.
SYNCRIP associates with pre-mRNA and mature mRNA complexes, and isoform 3 may support vesicle-based mRNA transport via synaptotagmins.
SYNCRIP is an hnRNP implicated in mRNA processing. It promotes MYC mRNA stability as part of the CRD-mediated complex, contributes to APOB mRNA editing, may participate in translationally coupled mRNA turnover, and is a component of the GAIT translation-inhibition complex.
SYNCRIP is also called hnRNP-Q, HNRNPQ, HNRNPQ1, NSAP1, GRY-RBP and dJ3J17.2, and UniProt names it heterogeneous nuclear ribonucleoprotein Q. Alternative splicing gives multiple isoforms, and isoforms 1 and 3 have distinct reported roles in APOB editing and mRNA transport.
Mouse and rat both carry a Syncrip ortholog of the human gene. Human SYNCRIP also has a pseudogene on the short arm of chromosome 20. Check the datasheet of any product for its validated reactivity.
Other hnRNPs, RNA-editing factors and mRNA-regulation partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60506; product specifications from Assay Genie datasheets.