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CYFIP2
CYFIP2 (cytoplasmic FMR1 interacting protein 2, also known as PIR121) is a member of the CYFIP family and a component of the SCAR/WAVE complex. It has been linked to T-cell adhesion, p53-dependent apoptosis and endosomal signalling in neurons. Browse Assay Genie's current range of CYFIP2 research reagents below, or read on for the biology behind the target.
CYFIP2 is involved in T-cell adhesion and in p53/TP53-dependent induction of apoptosis. UniProt reports that it does not bind RNA. As a component of the WAVE1 complex, CYFIP2 is required for BDNF-NTRK2 endocytic trafficking and for signalling from early endosomes. The NCBI Gene summary predicts that it enables small GTPase binding activity, and it is part of the SCAR complex.
The CYFIP2 protein belongs to the CYFIP family and is classed by HGNC in the SCAR/WAVE complex gene group. UniProt lists its subcellular locations as the cytoplasm, the nucleus, the perinuclear region of the cytoplasm and the synaptosome. NCBI Gene describes it as located in the cytosol, the perinuclear region of the cytoplasm and the synapse. The mouse ortholog is Cyfip2.
The CYFIP2 gene is implicated in several cellular processes, including cell-cell adhesion, positive regulation of proteolysis and regulation of postsynapse assembly. It is also implicated in developmental and epileptic encephalopathy 65, which makes it a point of interest for work on neurodevelopmental disease. The alias PIR121 is still widely used in the literature, so both names are worth including when searching for CYFIP2 research.
As part of the WAVE1 complex, CYFIP2 is required for BDNF-NTRK2 endocytic trafficking and signalling from early endosomes.
CYFIP2 is located at the synapse and is involved in regulating postsynapse assembly.
CYFIP2 is implicated in developmental and epileptic encephalopathy 65, supporting studies of its role in disease mechanisms.
CYFIP2 is involved in p53-dependent induction of apoptosis and in T-cell adhesion, two processes studied in cell biology and immunology.
CYFIP2 is involved in T-cell adhesion and p53-dependent induction of apoptosis. As a component of the WAVE1 complex, it is required for BDNF-NTRK2 endocytic trafficking and signalling from early endosomes. It is also part of the SCAR complex and is predicted to bind small GTPases.
PIR121 is an alias for CYFIP2, whose HGNC name is cytoplasmic FMR1 interacting protein 2. The protein is a member of the CYFIP family. The two names refer to the same gene, so literature searches for either term are relevant to CYFIP2.
NCBI Gene reports that CYFIP2 is implicated in developmental and epileptic encephalopathy 65. A mouse ortholog, Cyfip2, is recognised. Check the datasheet of any product for its validated reactivity.
Other CYFIP family members, SCAR/WAVE complex components and neurotrophin signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96F07; product specifications from Assay Genie datasheets.
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