MAT2A
MAT2A (methionine adenosyltransferase 2A) is an enzyme that catalyses the formation of S-adenosylmethionine from methionine and ATP. Also known as SAMS2, MATA2, MATII and MAT-II, it supplies AdoMet, the key methyl donor in cellular processes. Browse Assay Genie's current range of MAT2A research reagents below, or read on for the biology behind the target.
MAT2A catalyses the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. According to UniProt, the reaction comprises two steps that are both catalysed by the same enzyme: formation of AdoMet and triphosphate, followed by hydrolysis of the triphosphate. The product, AdoMet, is described in the NCBI Gene summary as the key methyl donor in cellular processes, which places the enzyme at the point where methionine and ATP are converted into a methylation substrate.
The MAT2A gene encodes the protein recorded in UniProt as S-adenosylmethionine synthase isoform type-2, and it is classified under EC 2.5.1.6. It belongs to the AdoMet synthase family, and HGNC places it in the methionine adenosyltransferase family. Related genes in this group include MAT1A, and the MAT2B gene is a separately named locus that appears among related targets. Mouse and rat both carry an ortholog named Mat2a, which allows the enzyme to be studied across common model species.
The gene has gone by several names. HGNC lists SAMS2, MATA2, MATII and MAT-II as aliases, and the previous name was methionine adenosyltransferase II, alpha. These variants are useful to know when searching the literature for an MAT2A antibody, an MAT2A ELISA kit or other tools to study the MAT2A protein, since older papers may use the MAT-II designation.
MAT2A produces AdoMet, the key methyl donor in cellular processes, so it is a natural focus for studies of methyl-group supply.
The enzyme converts methionine and ATP into AdoMet, making it a central node for investigating methionine utilisation.
Both AdoMet formation and subsequent triphosphate hydrolysis are catalysed by the same enzyme, an interesting two-step system to dissect.
As a member of the methionine adenosyltransferase family alongside MAT1A, MAT2A supports comparative work on AdoMet synthase biology.
MAT2A catalyses the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The reaction has two steps, both catalysed by the same enzyme: AdoMet and triphosphate are formed, then the triphosphate is hydrolysed. AdoMet is the key methyl donor in cellular processes.
HGNC lists the aliases SAMS2, MATA2, MATII and MAT-II. The previous gene name was methionine adenosyltransferase II, alpha, and UniProt names the protein S-adenosylmethionine synthase isoform type-2. The enzyme is assigned EC 2.5.1.6.
Yes. Both mouse and rat have an ortholog named Mat2a, so the gene can be studied in common rodent models. Reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other methionine adenosyltransferase family members and related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P31153; product specifications from Assay Genie datasheets.