TNNC1
TNNC1 (troponin C1, slow skeletal and cardiac type) is the calcium-binding subunit of the troponin complex, a central regulator of striated muscle contraction. It is also known as TNNC, and was previously named troponin C type 1 (slow). Browse Assay Genie's current range of TNNC1 research reagents below, or read on for the biology behind the target.
Troponin is the central regulatory protein of striated muscle contraction and, together with tropomyosin, sits on the actin filament. It has three subunits: TnI, the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by the TNNC1 gene. Calcium binding to TnC abolishes the inhibitory action of TnI on actin filaments. This allows actin to interact with myosin, ATP to be hydrolysed and tension to be generated.
The TNNC1 protein, troponin C, slow skeletal and cardiac muscles, belongs to the troponin C family. HGNC places it in the EF-hand domain containing group and in the group of troponin complex subunits. In humans the gene lies on chromosome 3, and the mouse ortholog is Tnnc1. The slow skeletal and cardiac designation in its name distinguishes it from TNNC2, the other troponin C gene.
Mutations in the TNNC1 gene are associated with dilated cardiomyopathy type 1Z, linking this calcium sensor of the contractile apparatus to inherited heart muscle disease. The symbol TNNC1 replaced the earlier symbol TNNC, and the gene name was formerly given as troponin C type 1 (slow). Because TNNC1 couples calcium signals to the actin-myosin interaction, it is a frequent subject in studies of cardiac and slow skeletal muscle regulation.
TnC is the calcium sensor of troponin, so TNNC1 is central to studies of how calcium releases TnI inhibition and enables actin-myosin interaction.
Mutations in TNNC1 are associated with dilated cardiomyopathy type 1Z, making it relevant to inherited heart muscle disease research.
Troponin with tropomyosin on the actin filament controls contraction; TNNC1 is a key subunit for dissecting this regulatory complex.
As the slow skeletal and cardiac troponin C, TNNC1 supports comparison of cardiac and slow skeletal muscle regulation with other striated muscle types.
TNNC1 encodes troponin C, the calcium-binding subunit of troponin. When calcium binds TnC, the inhibitory action of TnI on actin filaments is abolished, allowing actin to interact with myosin, ATP to be hydrolysed and tension to be generated in striated muscle.
The HGNC full name is troponin C1, slow skeletal and cardiac type. UniProt calls the protein troponin C, slow skeletal and cardiac muscles. The previous symbol was TNNC, and the previous name was troponin C type 1 (slow). It is often abbreviated TnC.
Mutations in TNNC1 are associated with dilated cardiomyopathy type 1Z. The mouse ortholog is Tnnc1, which allows the gene to be studied in murine models; check the datasheet of any product for its validated reactivity.
Other troponin C family members and troponin complex partners involved in striated muscle regulation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P63316; product specifications from Assay Genie datasheets.