Troponin I, also known as TNNC1, is part of the troponin complex. The troponin complex is made up of three subunits: troponin I (TnI), troponin T (TnT), and troponin C (TnC). The inhibitory subunit of troponin I, inhibits actin-myosin interactions and therefore induces striated muscle relaxation. It binds to actin in thin myofilaments and holds the actin-tropomyosinthe complex in place. Because of it, myosin is unable to connect actin in relaxed muscle. Calcium binds to Troponin C, causing conformational changes that result in tropomyosin leaving the binding site for myosin on actin, which causes muscle contraction. Human Troponin C/TNNC1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Troponin C/TNNC1 Recombinant Protein (RPES4392)
Product Code:
RPES4392
Size:
20µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
CMD1Z,CMH13,TN-C,TNC,TNNC
Accession:
NP_003271.1
Sequence:
Met 1-Glu161
Fusion tag:
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human TNNC1 (NP_003271.1) (Met1-Glu161) was expressed and purified.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
18.4 kDa
AP Mol Mass:
20 kDa
Formulation:
Lyophilized from sterile 150 mM NaCl, 10 mM Na2HPO4, pH 7.5
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
