PTPRQ
PTPRQ (protein tyrosine phosphatase receptor type Q, DFNB84) is a receptor-type protein-tyrosine phosphatase that dephosphorylates phosphatidylinositol phosphates, preferring PIP3. It contributes to adipogenesis in mesenchymal stem cells and to hair bundle maturation in the inner ear. Browse Assay Genie's current range of PTPRQ research reagents below, or read on for the biology behind the target.
PTPRQ dephosphorylates phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with a preference for PIP3. It can remove phosphate from both the D3 and D5 positions of the inositol ring. Its tyrosine-protein phosphatase activity is low in vitro, and the relevance of that activity in vivo is unclear.
In mesenchymal stem cells and preadipocyte cells, PTPRQ regulates the phosphorylation state of AKT1 by controlling PIP3 levels, and it plays an important role in adipogenesis. In the inner ear, PTPRQ is required for hair bundle maturation, the process that enables hair cells to detect and transmit sound and balance signals, and so affects auditory function. It may act by regulating phosphatidylinositol 4,5-bisphosphate (PIP2) in the basal region of hair bundles. UniProt places the protein in stereocilia, the apical cell membrane and the basal cell membrane.
The PTPRQ gene encodes a member of the type III receptor-like protein-tyrosine phosphatase family, belonging to receptor class 2A of the protein-tyrosine phosphatase family. HGNC also groups it among fibronectin type III domain containing proteins. NCBI Gene describes roles in cellular proliferation and differentiation. Mutations at this locus have been linked to autosomal recessive deafness, which is reflected in the previous name and alias DFNB84 (deafness, autosomal recessive 84). Mouse and rat both carry a Ptprq ortholog.
PTPRQ is required for hair bundle maturation, which allows hair cells to detect and transmit sound and balance signals.
Mutations at the PTPRQ locus are linked to autosomal recessive deafness, known as DFNB84.
PTPRQ dephosphorylates PIP3 and other phosphatidylinositol phosphates at the D3 and D5 positions, making it a tool for studying lipid signalling.
PTPRQ regulates PIP3 levels and AKT1 phosphorylation in mesenchymal stem cells and preadipocytes, influencing adipogenesis.
PTPRQ is a phosphatidylinositol phosphatase that preferentially dephosphorylates PIP3, removing phosphate from the D3 and D5 positions. It regulates AKT1 phosphorylation in mesenchymal stem cells and preadipocytes, supports adipogenesis, and is required for hair bundle maturation and normal auditory function.
DFNB84 is an alias and previous symbol for the gene, whose previous name was deafness, autosomal recessive 84. It reflects the link between mutations at this locus and autosomal recessive deafness. The current HGNC name is protein tyrosine phosphatase receptor type Q.
Mouse and rat both have a Ptprq ortholog of the human gene. Human PTPRQ belongs to the receptor class 2A subfamily of protein-tyrosine phosphatases. Check the datasheet of any product for its validated reactivity.
Other receptor-type protein tyrosine phosphatases, phosphoinositide pathway proteins and signalling partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UMZ3; product specifications from Assay Genie datasheets.