HSPA12B
HSPA12B (heat shock protein family A (Hsp70) member 12B) is a distant member of the mammalian Hsp70 family, also known as dJ1009E24.2 and C20orf60. It contains an atypical Hsp70 ATPase domain and has been linked to susceptibility to atherosclerosis. Browse Assay Genie's current range of HSPA12B research reagents below, or read on for the biology behind the target.
HSPA12B is the protein encoded by a gene that belongs to the heat shock protein 70 family. According to the NCBI Gene summary, the protein contains an atypical Hsp70 ATPase domain, which is why it is considered only a distant member of the mammalian Hsp70 group. Its precise molecular function is not described in the UniProt record used for this page, and no subcellular location has been annotated there, so researchers should treat the mechanism as an open question and consult the primary literature for functional studies.
The HSPA12B gene is catalogued by HGNC within the heat shock 70kDa proteins gene group. The protein is listed in UniProt as heat shock 70 kDa protein 12B. Alternative splicing of the gene produces multiple transcript variants that encode different isoforms, a point worth bearing in mind when choosing an HSPA12B antibody, an HSPA12B ELISA kit or other reagents that depend on which region of the protein is recognised. The mouse ortholog is Hspa12b.
The gene has previously been named chromosome 20 open reading frame 60 (C20orf60) and heat shock 70kD protein 12B, and it also carries the clone-derived alias dJ1009E24.2. The NCBI Gene summary notes that the gene may be involved in susceptibility to atherosclerosis, which has made it of interest in cardiovascular research. Within the wider Hsp70 family, better characterised chaperones such as HSPA5, HSPA8 and HSPA9 provide useful points of comparison when studying how HSPA12B differs from classical family members.
HSPA12B carries an atypical Hsp70 ATPase domain, making it a useful distant relative for comparative studies of the Hsp70 family.
The gene may be involved in susceptibility to atherosclerosis, so HSPA12B is studied in the context of vascular disease.
Alternative splicing yields multiple transcript variants encoding different isoforms, which makes HSPA12B relevant to transcript and protein isoform analysis.
A mouse ortholog, Hspa12b, is recognised, supporting comparative work between human and mouse systems.
The available annotation describes HSPA12B as a protein with an atypical Hsp70 ATPase domain and a distant member of the mammalian Hsp70 family. The NCBI Gene summary says the gene may be involved in susceptibility to atherosclerosis. A detailed biochemical function is not given in the source records.
HSPA12B is also known as dJ1009E24.2 and C20orf60. Earlier names include chromosome 20 open reading frame 60 and heat shock 70kD protein 12B. UniProt lists it as heat shock 70 kDa protein 12B. Alternative splicing gives multiple transcript variants encoding different isoforms.
A mouse ortholog, Hspa12b, is recorded for the human HSPA12B gene. Researchers working across species should check sequence conservation for their region of interest, and check the datasheet of any product for its validated reactivity.
Other members of the Hsp70 family of heat shock proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96MM6; product specifications from Assay Genie datasheets.