LMO4
LMO4 (LIM domain only 4) is a cysteine-rich transcription cofactor that contains two LIM domains but no DNA-binding homeodomain. It helps establish motor neuron identity and may act as a transcriptional regulator or as an oncogene. Browse Assay Genie's current range of LMO4 research reagents below, or read on for the biology behind the target.
LMO4 functions as a transcription cofactor. In UniProt it is described as playing a role in establishing motor neuron identity, working in concert with MNX1. It acts, at least in part, by disrupting LDB1-LHX3 complexes, which negatively modulates interneuron genes in motor neurons. In this way LMO4 influences which gene programmes are active in a developing neuronal population, without binding DNA itself.
The LMO4 gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. This architecture is consistent with a role as an adaptor that works through protein-protein interactions rather than direct promoter binding. According to the NCBI Gene summary, the encoded protein may act as a transcriptional regulator or as an oncogene. HGNC places the gene in the LIM domain containing group, and the mouse ortholog is Lmo4.
Researchers studying LMO4 typically focus on its part in transcriptional complexes, on neuronal specification and on its possible oncogenic activity. The related LIM-only proteins LMO2 and LMO3 are useful points of comparison when examining how this small protein family regulates gene expression. Any LMO4 antibody, LMO4 ELISA kit or LMO4 protein reagent should be matched to the species and application of your experiment.
LMO4 helps establish motor neuron identity together with MNX1, making it a relevant target for studies of neuronal specification.
LMO4 disrupts LDB1-LHX3 complexes, so it is used to study how cofactors reshape transcription factor assemblies.
By negatively modulating interneuron genes in motor neurons, LMO4 informs work on how neuronal subtype programmes are separated.
The NCBI Gene summary notes that LMO4 may function as an oncogene, which motivates investigation of its role in cancer biology.
LMO4 is a transcription cofactor. It plays a role in establishing motor neuron identity in concert with MNX1, acting at least in part to disrupt LDB1-LHX3 complexes and so negatively modulate interneuron genes in motor neurons. It does not bind DNA directly.
LMO4 stands for LIM domain only 4, and UniProt names the protein LIM domain transcription factor LMO4. It is a cysteine-rich protein with two LIM domains and no DNA-binding homeodomain. HGNC lists it in the LIM domain containing gene group, with no alternative symbols.
The NCBI Gene summary states that LMO4 may play a role as a transcriptional regulator or as an oncogene. The mouse ortholog is Lmo4. Check the datasheet of any product for its validated reactivity.
Other LIM domain only proteins that share the LIM domain architecture with LMO4.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P61968; product specifications from Assay Genie datasheets.