SP7
SP7 (Sp7 transcription factor), also known as osterix or OSX, is a bone-specific zinc-finger transcription factor of the Sp family. It acts as a transcriptional activator and is essential for osteoblast differentiation and bone formation. Browse Assay Genie's current range of SP7 research reagents below, or read on for the biology behind the target.
SP7 is a transcriptional activator that is essential for osteoblast differentiation. It binds DNA in a sequence-specific manner, recognising SP1 and EKLF consensus sequences as well as other G/C-rich sequences. The protein is described as a bone-specific transcription factor and is required for both osteoblast differentiation and bone formation, which makes it a central regulator in skeletal biology.
The SP7 gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors and belongs to the Sp1 C2H2-type zinc-finger protein family. HGNC places it in the C2H2-type zinc finger group and the Sp transcription factors group. Sp family proteins are characterised by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs, which mediate DNA binding. The SP7 protein localises to the nucleus, in keeping with its role in regulating gene expression. A mouse ortholog, Sp7, is recorded for the gene.
SP7 is widely referred to by the alias osterix (OSX). Researchers studying osteoblast lineage commitment, bone development and bone formation use the SP7 gene and protein as a marker and mechanistic entry point, and the related Sp family member SP1 shares the consensus sequences that SP7 recognises.
SP7 is a transcriptional activator essential for osteoblast differentiation, so it is a key readout when studying how bone-forming cells mature.
As a bone-specific transcription factor required for bone formation, SP7 is relevant to studies of skeletal development and bone biology.
SP7 binds SP1 and EKLF consensus sequences and other G/C-rich sequences, making it a useful model for Sp family DNA binding.
With an amino-terminal trans-activation domain and three C-terminal zinc fingers, SP7 informs work on Sp/XKLF domain organisation and function.
SP7 is a nuclear transcriptional activator that is essential for osteoblast differentiation. It binds SP1 and EKLF consensus sequences and other G/C-rich DNA sequences. It is described as a bone-specific transcription factor required for osteoblast differentiation and bone formation.
Yes. Osterix and OSX are aliases for SP7, the HGNC-approved symbol for the Sp7 transcription factor gene. UniProt lists the protein as Transcription factor Sp7. The names refer to the same gene and protein, so searches under any of them cover the same target.
SP7 belongs to the Sp1 C2H2-type zinc-finger family and the Sp subfamily of Sp/XKLF transcription factors. A mouse ortholog, also named Sp7, is recorded. Check the datasheet of any product for its validated reactivity.
Other Sp family transcription factors and related nuclear regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TDD2; product specifications from Assay Genie datasheets.