C1QL1
C1QL1 (complement C1q like 1) is a secreted member of the C1q and TNF related gene group, also known as C1q-related factor, CRF, C1QRF, C1QTNF14 and CTRP14. It is linked to the regulation of excitatory synapse formation on hippocampal neurons. Browse Assay Genie's current range of C1QL1 research reagents below, or read on for the biology behind the target.
C1QL1 is a secreted protein that may regulate the number of excitatory synapses formed on hippocampal neurons. According to UniProt, it has no effect on inhibitory synapses, which points to a selective role in shaping excitatory connectivity rather than synapse formation in general.
The NCBI Gene summary, based on predictions from the Alliance of Genome Resources, adds further context. The C1QL1 protein is predicted to enable signalling receptor binding and to be involved in maintaining synapse structure and in trans-synaptic signalling that modulates synaptic transmission. It is also predicted to act upstream of or within motor learning and neuron remodelling. Predicted locations include the extracellular region, the presynapse, the synaptic cleft and the climbing fibre. These assignments are computational, so experimental work remains important for confirming them.
The C1QL1 gene is classified by HGNC within the C1q and TNF related group. The approved name, complement C1q like 1, replaces the earlier name complement component 1, q subcomponent-like 1. The protein is also called C1q-related factor, and the aliases CRF, C1QRF, C1QTNF14 and CTRP14 appear in the literature. The mouse ortholog is C1ql1, which makes rodent models a natural route for studying its function in neural circuits. Researchers studying C1QL1 are mostly interested in synapse biology, hippocampal development and secreted regulators of neuronal connectivity.
C1QL1 may regulate the number of excitatory synapses formed on hippocampal neurons, making it a candidate regulator of synaptic connectivity.
C1QL1 is predicted to take part in trans-synaptic signalling and to modulate synaptic transmission from the synaptic cleft.
C1QL1 is predicted to contribute to maintaining synapse structure, a topic relevant to neuronal circuit stability.
C1QL1 is predicted to act upstream of or within motor learning and neuron remodelling, including at the climbing fibre.
C1QL1 is a secreted protein that may regulate the number of excitatory synapses formed on hippocampal neurons. UniProt notes that it has no effect on inhibitory synapses. Predictions also link it to synapse structure maintenance and trans-synaptic signalling.
C1QL1 is also called C1q-related factor, CRF, C1QRF, C1QTNF14 and CTRP14. HGNC lists the full name as complement C1q like 1, and the previous name as complement component 1, q subcomponent-like 1.
Yes, the mouse ortholog is C1ql1, so findings in mouse models can inform work on the human protein. C1QL1 belongs to the C1q and TNF related gene group. Check the datasheet of any product for its validated reactivity.
Other C1q and TNF related proteins and synaptic signalling targets may be listed here as pages become available.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75973; product specifications from Assay Genie datasheets.