DPF2
DPF2 (double PHD fingers 2, also known as ubi-d4, BAF45d, SMARCG2 or REQ) is a zinc finger protein of the requiem/DPF family that regulates transcription by binding modified histones. It is a subunit of the BAF complex and influences haematopoietic cell differentiation and apoptosis. Browse Assay Genie's current range of DPF2 research reagents below, or read on for the biology behind the target.
DPF2 plays an active role in transcriptional regulation by binding modified histones H3 and H4. It acts as a negative regulator of myeloid differentiation of haematopoietic progenitor cells, and it might also contribute to the development and maturation of lymphoid cells. DPF2 is additionally involved in regulation of the non-canonical NF-kappa-B pathway.
The protein belongs to the requiem/DPF family and is a member of the d4 domain family, which is characterised by a zinc finger-like structural motif. The HGNC classifies the DPF2 gene within the C2H2-type zinc fingers, PHD finger proteins and BAF complex subunits groups. UniProt records the protein in the nucleus and the cytoplasm. The mouse ortholog is Dpf2.
NCBI Gene describes DPF2 as a transcription factor necessary for the apoptotic response following deprivation of survival factors, and notes that it likely serves a regulatory role in rapid haematopoietic cell growth and turnover. The earlier names reflect this history: requiem (apoptosis response zinc finger gene) and D4, zinc and double PHD fingers family 2. The DPF2 gene is also considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic and pituitary tumours.
DPF2 binds modified histones H3 and H4, making it a useful subject for studies of histone recognition and transcriptional regulation.
DPF2 negatively regulates myeloid differentiation of haematopoietic progenitor cells and may influence lymphoid development and maturation.
DPF2 is necessary for the apoptotic response after deprivation of survival factors, linking it to cell turnover.
DPF2 is involved in regulating the non-canonical NF-kappa-B pathway, relevant to studies of immune and haematopoietic signalling.
DPF2 regulates transcription by binding modified histones H3 and H4. It negatively regulates myeloid differentiation of haematopoietic progenitor cells, may contribute to lymphoid cell development, and is involved in the non-canonical NF-kappa-B pathway. It is also needed for apoptosis after loss of survival factors.
DPF2 is also called ubi-d4, BAF45d, SMARCG2 and REQ. Its earlier names were requiem (apoptosis response zinc finger gene) and D4, zinc and double PHD fingers family 2. UniProt lists the protein name as zinc finger protein ubi-d4. Researchers searching for a DPF2 antibody or DPF2 ELISA kit may meet any of these names.
NCBI Gene considers the DPF2 gene a candidate for multiple endocrine neoplasia type I, an inherited cancer syndrome involving parathyroid, enteropancreatic and pituitary tumours. The mouse ortholog is Dpf2. Check the datasheet of any product for its validated reactivity.
Other requiem/DPF family members, BAF complex subunits and NF-kappa-B pathway proteins that may be of interest alongside DPF2.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92785; product specifications from Assay Genie datasheets.