IFNA1
IFNA1 (interferon alpha 1, also known as IFN-alphaD, IFNA13, IFL and IFN) is a secreted type I interferon cytokine produced in response to viral infection. It has antiviral, antiproliferative and immunomodulatory properties and is a key part of the innate immune response. Browse Assay Genie's current range of IFNA1 research reagents below, or read on for the biology behind the target.
IFNA1 is a cytokine of the type I (alpha/beta) interferon family. It is produced in response to viral infection as a key part of the innate immune response, and UniProt notes that IFN-alpha is produced by macrophages and has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Beyond its antiviral role, the cytokine has potent antiproliferative and immunomodulatory properties.
Like other type I interferons, IFNA1 binds a plasma membrane receptor made of IFNAR1 and IFNAR2. This receptor is ubiquitously expressed, so the cytokine is able to act on virtually all body cells. The mature protein is secreted. Researchers studying IFNA1 signalling often work with the IFNA1 protein, and measure it in biological samples with an IFNA1 ELISA kit or detect it with an IFNA1 antibody.
The IFNA1 gene is a member of the alpha interferon gene cluster on chromosome 9, and is a member of the gene group of interferons that are encoded by multiple genes. Previous or alternative symbols include IFNA@, IFL, IFN, IFN-ALPHA, IFNA13 and IFN-alphaD. The mouse and rat orthologs are both named Ifna1. IFNA1 is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia.
IFNA1 is produced in response to viral infection as a key part of the innate immune response, with potent antiviral activity.
IFNA1 binds the IFNAR1 and IFNAR2 receptor, which is ubiquitously expressed, allowing it to act on virtually all body cells.
As a type I interferon, IFNA1 has antiproliferative and immunomodulatory properties relevant to studies of immune regulation.
IFNA1 is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia.
IFNA1 is a secreted type I interferon that is produced in response to viral infection. It has antiviral, antiproliferative and immunomodulatory effects. Interferon stimulates the production of a protein kinase and an oligoadenylate synthetase, and it signals through the IFNAR1 and IFNAR2 receptor.
The HGNC name is interferon alpha 1, and UniProt lists the protein as interferon alpha-1. Aliases and previous symbols include IFNA@, IFL, IFN, IFN-ALPHA, IFNA13 and IFN-alphaD. The general term IFN-alpha is also used for the wider group of alpha interferons.
Mouse and rat both have an ortholog named Ifna1. IFNA1 belongs to the type I interferon family and sits in the alpha interferon gene cluster in humans. Check the datasheet of any product for its validated reactivity.
Related interferon targets and pathway partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P0DY56; product specifications from Assay Genie datasheets.