MADCAM1
MADCAM1 (mucosal vascular addressin cell adhesion molecule 1, also known as MACAM1) is an endothelial cell adhesion molecule of the immunoglobulin family. It is expressed by mucosal venules and helps direct lymphocyte traffic into mucosal tissues. Browse Assay Genie's current range of MADCAM1 research reagents below, or read on for the biology behind the target.
MADCAM1 is a cell adhesion leukocyte receptor expressed by mucosal venules. It helps to direct lymphocyte traffic into mucosal tissues, including the Peyer patches and the intestinal lamina propria. The MADCAM1 protein can bind both integrin alpha-4/beta-7 and L-selectin, which allows it to regulate both the passage and the retention of leukocytes. NCBI Gene describes it as interacting preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin and VLA-4 (alpha4beta1) on myeloid cells, directing leukocytes into mucosal and inflamed tissues.
The MADCAM1 gene encodes a membrane protein that belongs to the immunoglobulin family and is similar to ICAM1 and VCAM1. HGNC places it in the immunoglobulin like domain containing group and the Ig-like cell adhesion molecule family. At least seven alternatively spliced transcripts encoding different protein isoforms have been reported, although the full-length nature of some variants has not been determined.
Isoform differences affect function. According to UniProt, isoform 2, which lacks the mucin-like domain, may be specialised in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. Orthologous genes are named Madcam1 in both mouse and rat, so the target can be studied in common rodent models. Researchers working on MADCAM1 antibody, MADCAM1 ELISA kit or MADCAM1 protein workflows will mainly be interested in its role as a mucosal addressin for lymphocyte homing.
MADCAM1 is expressed by mucosal venules and helps direct lymphocyte traffic into the Peyer patches and intestinal lamina propria.
By binding integrin alpha-4/beta-7 and L-selectin, MADCAM1 regulates both the passage and the retention of leukocytes.
MADCAM1 directs leukocytes into mucosal and inflamed tissues, making it relevant to studies of leukocyte recruitment.
As an immunoglobulin family member similar to ICAM1 and VCAM1, MADCAM1 is a model for endothelial adhesion and isoform-specific function.
MADCAM1 is a cell adhesion receptor on mucosal venules that helps direct lymphocytes into mucosal tissues such as the Peyer patches and intestinal lamina propria. It binds integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.
MADCAM1 is the HGNC symbol for mucosal vascular addressin cell adhesion molecule 1, and MACAM1 is a listed alias. At least seven alternatively spliced transcripts have been found. UniProt notes that isoform 2 lacks the mucin-like domain and may support integrin alpha-4/beta-7-dependent adhesion strengthening.
Yes. Mouse and rat both have an ortholog named Madcam1. In humans, the protein is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. Please check the datasheet of any product for its validated reactivity.
Other immunoglobulin-family adhesion molecules, selectins and integrin subunits that act alongside MADCAM1 in leukocyte trafficking.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13477; product specifications from Assay Genie datasheets.