GALP
GALP (galanin like peptide, also known as GAL) is a secreted neuropeptide of the galanin family. It binds galanin receptors and has been linked to hypothalamic regulation of metabolism and reproduction. Browse Assay Genie's current range of GALP research reagents below, or read on for the biology behind the target.
GALP is a secreted peptide that belongs to the galanin family of neuropeptides. It binds galanin receptors 1, 2 and 3, with the highest affinity for galanin receptor 3 (GALR3). In the cutaneous microvasculature, GALP shows potent, dose-dependent vasoconstrictor and anti-oedema activity, and this effect does not appear to be mediated through GALR1 or GALR2. It also exhibits antimicrobial activity against Gram-negative bacteria, inducing blebbing of the bacterial membrane.
The human GALP gene encodes the Galanin-like peptide precursor, and mouse and rat each have a corresponding Galp ortholog. HGNC classes GALP in the neuropeptides gene group, and the symbol GAL is listed as an alias. The NCBI Gene summary associates the encoded protein with processes in the central nervous system, including hypothalamic regulation of metabolism and reproduction.
A splice variant of the gene encodes a separate peptide, termed alarin. Alarin has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumours. These features make the GALP gene and its products of interest to researchers studying neuroendocrine signalling, microvascular biology and innate antimicrobial defence.
GALP has been implicated in hypothalamic regulation of metabolism and reproduction, making it relevant to studies of central nervous system control of these processes.
GALP binds galanin receptors 1, 2 and 3, with highest affinity for GALR3, so it is useful for comparing galanin family ligand pharmacology.
GALP produces vasoconstrictor and anti-oedema effects in the cutaneous microvasculature through a route that appears independent of GALR1 and GALR2.
GALP acts against Gram-negative bacteria and induces membrane blebbing, while the alarin splice product is active against E. coli.
GALP is a secreted galanin family neuropeptide. It binds galanin receptors 1, 2 and 3, has been implicated in hypothalamic regulation of metabolism and reproduction, and causes vasoconstriction and anti-oedema effects in cutaneous microvasculature. It also shows antimicrobial activity against Gram-negative bacteria.
Alarin is a peptide encoded by a splice variant of the GALP gene. It has vasoactive properties, shows antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumours. GALP is also listed under the alias GAL.
Yes. Both mouse and rat have a Galp ortholog of the human gene, so rodent models can be used to study its biology. Check the datasheet of any product for its validated reactivity.
Galanin family neuropeptides and galanin receptors with related research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UBC7; product specifications from Assay Genie datasheets.