FSCN1
FSCN1 (fascin actin-bundling protein 1) is an actin-binding protein that organises filamentous actin into parallel bundles and supports the formation of cell protrusions. It is also known as fascin, p55 and SNL. Browse Assay Genie's current range of FSCN1 research reagents below, or read on for the biology behind the target.
FSCN1 is an actin-binding protein that contains two major actin-binding sites. It organises filamentous actin (F-actin) into parallel bundles and plays a role in the organisation of actin filament bundles and in the formation of microspikes, membrane ruffles and stress fibres. It is important for building a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. FSCN1 also mediates reorganisation of the actin cytoskeleton and axon growth cone collapse in response to NGF.
The FSCN1 gene encodes a member of the fascin family of actin-binding proteins. The fascin protein is found in the cytosol and cell cortex, and is associated with the cytoskeleton, stress fibres, filopodia, invadopodia, microvilli and cell junctions. It is required for the formation of actin-based cellular protrusions and plays a critical role in cell migration, motility, adhesion and cellular interactions. Mouse and rat orthologs are both named Fscn1, and a related family member, FSCN2, is also recognised.
Expression of the FSCN1 gene is known to be regulated by several microRNAs. Overexpression may play a role in the metastasis of multiple types of cancer by increasing cell motility, and FSCN1 expression is a marker for Reed-Sternberg cells in Hodgkin's lymphoma. Earlier names reflect the sea urchin fascin homologue, including singed (Drosophila)-like. A pseudogene of this gene is located on the long arm of chromosome 15.
FSCN1 is required for filopodia and other protrusions, and plays a critical role in cell migration, motility, adhesion and cellular interactions.
Overexpression of FSCN1 may contribute to metastasis in multiple cancer types by increasing cell motility.
FSCN1 organises F-actin into parallel bundles, making it a model for studying microspikes, membrane ruffles and stress fibres.
FSCN1 expression marks Reed-Sternberg cells in Hodgkin's lymphoma, linking the protein to lymphoma diagnostics research.
FSCN1 is an actin-binding protein with two major actin-binding sites that organises filamentous actin into parallel bundles. This supports filopodia, microspikes, membrane ruffles and stress fibres, and underpins cell motility and migration. It also mediates actin reorganisation and growth cone collapse in response to NGF.
The approved name is fascin actin-bundling protein 1, and the protein is called fascin. Aliases include p55, SNL and FLJ38511. Older names refer to the sea urchin fascin homologue, such as singed (Drosophila)-like. FSCN1 belongs to the fascin family, which also includes FSCN2.
Overexpression of FSCN1 may play a role in the metastasis of multiple cancer types by increasing cell motility, and it marks Reed-Sternberg cells in Hodgkin's lymphoma. Mouse and rat both carry an ortholog named Fscn1; check the datasheet of any product for its validated reactivity.
Other fascin family members and actin-cytoskeleton proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16658; product specifications from Assay Genie datasheets.