CAPN5
CAPN5 (calpain 5) is a calcium-regulated, non-lysosomal thiol protease of the calpain family, also known as nCL-3 or HTRA3. It acts as a large catalytic subunit in calpain signal transduction. Browse Assay Genie's current range of CAPN5 research reagents below, or read on for the biology behind the target.
CAPN5 is a calcium-regulated, non-lysosomal thiol protease. Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain consists of an invariant small subunit paired with one of a family of large subunits, and CAPN5 is one of those large subunits. It belongs to the peptidase C2 family.
Unlike some other calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV, which sets them apart structurally from the better-known members of the family. The human calpain 5 protein is classed by HGNC within the C2 domain containing and calpain gene groups, and the CAPN5 gene has mouse and rat orthologs, each named Capn5.
The name HTRA3 arose because of the significant similarity of CAPN5 to the Caenorhabditis elegans sex determination gene tra-3. The gene has also been listed under the previous name vitreoretinopathy, neovascular inflammatory, with the symbols ADNIV and VRNI among its aliases. Researchers studying calpain biology often compare CAPN5 with related large subunits such as CAPN1, CAPN2 and CAPN6, and with the shared small subunit CAPNS1.
CAPN5 is a calcium-dependent protease involved in signal transduction across a variety of cellular processes, making it relevant to calcium signalling studies.
As a large calpain subunit lacking calmodulin-like domain IV, CAPN5 is useful for comparing domain architecture and regulation across the calpain family.
Functional calpains pair an invariant small subunit with a large subunit, so CAPN5 is a model for studying large and small subunit partnerships.
The previous gene name, neovascular inflammatory vitreoretinopathy, and aliases ADNIV and VRNI link CAPN5 to nomenclature used in retinal disease research.
CAPN5 is a calcium-regulated, non-lysosomal thiol protease. Calpains are calcium-dependent cysteine proteases involved in signal transduction in various cellular processes, and CAPN5 acts as one of the large catalytic subunits that pairs with an invariant small subunit.
CAPN5 is called HTRA3 because of its significant similarity to the Caenorhabditis elegans sex determination gene tra-3. Other aliases include nCL-3, ADNIV and VRNI, and a previous name was vitreoretinopathy, neovascular inflammatory.
CAPN5 and CAPN6 lack a calmodulin-like domain IV, unlike some other calpains. CAPN5 has mouse and rat orthologs, both named Capn5; check the datasheet of any product for its validated reactivity.
Other calpain large subunits and the shared calpain small subunit, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15484; product specifications from Assay Genie datasheets.