TIE1
TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1, also known as JTK14 or TIE) is a transmembrane receptor tyrosine kinase that may modulate TEK/TIE2 activity. It contributes to the regulation of angiogenesis and blood vessel stability. Browse Assay Genie's current range of TIE1 research reagents below, or read on for the biology behind the target.
TIE1 is a transmembrane tyrosine-protein kinase that may modulate the activity of TEK/TIE2 and contribute to the regulation of angiogenesis. According to the NCBI Gene summary, the encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signalling through the endothelial receptor tyrosine kinase Tie2. This places TIE1 as a regulator of a key vascular signalling axis, rather than as a stand-alone driver of it.
Inhibition of Tie2 by TIE1 can be relieved. Cleavage of the TIE1 ectodomain removes the inhibition of Tie2, and this cleavage is mediated by multiple factors, including vascular endothelial growth factor. Studying the intact and cleaved forms of the receptor is therefore relevant to work on how vascular signals are integrated at the cell surface.
The TIE1 gene encodes a member of the protein kinase superfamily, in the Tyr protein kinase family and the Tie subfamily. HGNC places it in the fibronectin type III domain containing, immunoglobulin like domain containing, and tyrosine kinase with immunoglobulin like and EGF like domains gene groups. The protein is classified as EC 2.7.10.1 and localises to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed. The mouse ortholog is Tie1. Earlier HGNC names for the gene were tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1, and tyrosine kinase with immunoglobulin-like and EGF-like domains 1.
TIE1 contributes to the regulation of angiogenesis, making it a relevant target for studies of how new blood vessels form and are controlled.
TIE1 plays a critical role in blood vessel stability, supporting investigation of the mechanisms that maintain vessel integrity.
TIE1 inhibits angiopoietin 1 signalling through Tie2, so it is studied when dissecting regulation of this receptor pathway.
Ectodomain cleavage, mediated by factors including VEGF, relieves Tie2 inhibition, offering a route to study receptor shedding and signalling control.
TIE1 is a transmembrane tyrosine kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. It supports blood vessel stability by inhibiting angiopoietin 1 signalling through Tie2. Cleavage of its ectodomain, including by VEGF, relieves this inhibition.
TIE1 is also known as JTK14 and TIE. UniProt names the protein tyrosine-protein kinase receptor Tie-1. Earlier HGNC names included tyrosine kinase with immunoglobulin-like and EGF-like domains 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for the gene.
A mouse ortholog, Tie1, is recorded for the human gene. Researchers using mouse models should consider this relationship when interpreting results, and should check the datasheet of any product for its validated reactivity.
Tie2, angiopoietin and VEGF pathway partners relevant to angiogenesis and vascular stability research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35590; product specifications from Assay Genie datasheets.