TRA2A
TRA2A (transformer 2 alpha homolog) is a nuclear, sequence-specific RNA-binding protein that participates in the control of pre-mRNA splicing. It is also known as htra-2-alpha or AWMS1 and belongs to the splicing factor SR family. Browse Assay Genie's current range of TRA2A research reagents below, or read on for the biology behind the target.
TRA2A is a sequence-specific RNA-binding protein that takes part in the control of pre-mRNA splicing. According to the NCBI Gene summary, the phosphorylated nuclear protein binds to specific RNA sequences and plays a role in regulating how pre-mRNA transcripts are spliced. UniProt classifies it within the splicing factor SR family, and its subcellular location is the nucleus.
The TRA2A gene is a member of the transformer 2 homolog family and encodes a protein containing several RRM (RNA recognition motif) domains, which mediate its RNA binding. HGNC places the gene in the RNA binding motif containing group. Alternatively spliced transcript variants have been reported for the gene, so researchers studying the TRA2A protein should consider that more than one transcript can arise from it. The mouse ortholog is Tra2a.
The gene was originally named for its relationship to the Drosophila transformer 2 gene, and the previous HGNC name was transformer 2 alpha homolog (Drosophila). Other names in use include htra-2-alpha and AWMS1. A closely related family member, TRA2B, is also part of the transformer 2 homolog family and is often studied alongside TRA2A in work on splicing regulation.
TRA2A participates in the control of pre-mRNA splicing, making it a relevant factor for studying how splice site choice is regulated.
TRA2A is a sequence-specific RNA-binding protein with RRM domains that binds defined RNA sequences, supporting work on RNA recognition.
As a member of the splicing factor SR family, TRA2A is used to explore how SR proteins act in the nucleus.
Alternatively spliced transcript variants of TRA2A have been described, which is relevant for studies of isoform-specific gene expression.
TRA2A is a sequence-specific RNA-binding protein that participates in the control of pre-mRNA splicing. It is a phosphorylated nuclear protein that binds to specific RNA sequences through its RRM domains and belongs to the splicing factor SR family.
TRA2A is also called htra-2-alpha and AWMS1. Its full HGNC name is transformer 2 alpha homolog, previously transformer 2 alpha homolog (Drosophila), and UniProt lists it as Transformer-2 protein homolog alpha. The gene produces alternatively spliced transcript variants.
The name reflects homology to the Drosophila transformer 2 gene, and the mouse ortholog is Tra2a. TRA2A belongs to the transformer 2 homolog family alongside TRA2B. Check the datasheet of any product for its validated reactivity.
TRA2B, the other transformer 2 homolog family member, and further targets with similar names at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13595; product specifications from Assay Genie datasheets.