CD37
CD37 (CD37 molecule, also known as leukocyte antigen CD37, CD37 antigen or TSPAN26) is a cell-surface tetraspanin glycoprotein. It organises membrane microdomains that support receptor clustering and signalling, adhesion and migration in immune cells. Browse Assay Genie's current range of CD37 research reagents below, or read on for the biology behind the target.
CD37 is a structural component of tetraspanin-enriched microdomains (TERMs), specialised areas of the plasma membrane that act as platforms for receptor clustering and signalling. Through these microdomains it takes part in cell signal transduction, adhesion, migration and protein trafficking. Following ligand binding, two signalling pathways can be activated: one acts through phosphorylation by LYN and leads to cell death, while the other is a survival pathway involving activation of GSK3B.
In B-cells, CD37 is essential for clustering of the integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane. This in turn contributes to integrin-mediated antiapoptotic signalling through AKT. CD37 also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, and in their integrin-mediated adhesion. It negatively regulates IL-6 responses by interacting directly with SOCS3, which prevents constitutive IL-6 signalling. IL-6 inhibition can also occur through interaction with, and stabilisation of, DECTIN1/CLEC7A at the cell membrane, limiting its ability to promote IL-6 production.
The CD37 gene encodes a member of the transmembrane 4 superfamily, the tetraspanin family, whose members are cell-surface proteins characterised by four hydrophobic domains. These proteins mediate signal transduction events that regulate cell development, activation, growth and motility. CD37 is a cell-surface glycoprotein known to complex with integrins and other tetraspanins, and it may play a role in T-cell-B-cell interactions. Alternative splicing gives rise to multiple transcript variants encoding different isoforms. Mouse and rat orthologs, both named Cd37, are annotated.
CD37 links integrin clustering to AKT-dependent antiapoptotic signalling and to LYN- or GSK3B-associated pathways, making it a focus for studies of B-cell fate.
As a structural component of tetraspanin-enriched microdomains, CD37 is used to study receptor clustering, membrane organisation and protein trafficking.
CD37 contributes to the migration of dendritic cells and neutrophils to draining lymph nodes and to their integrin-mediated adhesion.
CD37 restrains IL-6 responses through SOCS3 and through stabilisation of DECTIN1/CLEC7A, offering a route to study control of constitutive IL-6 signalling.
CD37 is a structural component of tetraspanin-enriched microdomains that serve as platforms for receptor clustering and signalling. It supports adhesion, migration and protein trafficking, clusters ITGA4/ITGB1 integrin in B-cells, and negatively regulates IL-6 responses through SOCS3 and DECTIN1/CLEC7A.
CD37 is also called leukocyte antigen CD37, CD37 antigen and TSPAN26, the last reflecting its place in the tetraspanin family. The HGNC name is CD37 molecule. Alternative splicing of the CD37 gene produces multiple transcript variants that encode different isoforms.
Orthologs of the CD37 gene are annotated in mouse and rat, both named Cd37. The human protein belongs to the tetraspanin (TM4SF) family. Check the datasheet of any product for its validated reactivity.
Other CD molecules, B-cell and myeloid markers and adhesion-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11049; product specifications from Assay Genie datasheets.