NR4A2
NR4A2 (nuclear receptor subfamily 4 group A member 2, also known as NURR1, NOT, RNR1, HZF-3 and TINUR) is a transcriptional regulator of the NR4 nuclear hormone receptor subfamily. It is important for the differentiation and maintenance of meso-diencephalic dopaminergic neurons. Browse Assay Genie's current range of NR4A2 research reagents below, or read on for the biology behind the target.
NR4A2 is a transcriptional regulator that is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for the expression of a set of genes, including SLC6A3, SLC18A2, TH and DRD2, which are essential for mdDA neuron development. Researchers studying dopaminergic gene programmes therefore often examine the NR4A2 protein alongside these downstream targets.
The NR4A2 gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily and belongs to the nuclear hormone receptor family, NR4 subfamily. In HGNC it sits within the nuclear receptor subfamily 4 group A gene group, alongside NR4A1 and NR4A3. The encoded protein may act as a transcription factor, and UniProt records its subcellular location as both cytoplasm and nucleus. Mouse and rat both have an orthologous gene, Nr4a2. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
NR4A2 is also known as NURR1, NOT, RNR1, HZF-3 and TINUR, and its earlier HGNC name was nuclear receptor subfamily 4, group A, member 2. According to the NCBI Gene summary, mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophrenia and manic depression. Misregulation of the gene may be associated with rheumatoid arthritis. These links make NR4A2 a frequent subject in neuroscience and inflammation research.
NR4A2 is important for the differentiation and maintenance of meso-diencephalic dopaminergic neurons during development.
NR4A2 is crucial for expression of SLC6A3, SLC18A2, TH and DRD2, genes essential for mdDA neuron development.
Mutations in NR4A2 have been associated with disorders of dopaminergic dysfunction, including Parkinson disease.
NR4A2 has been linked to schizophrenia and manic depression, and its misregulation may be associated with rheumatoid arthritis.
NR4A2 is a transcriptional regulator important for the differentiation and maintenance of meso-diencephalic dopaminergic neurons during development. It is crucial for expression of genes such as SLC6A3, SLC18A2, TH and DRD2, which are essential for the development of these neurons.
NR4A2 is also called NURR1, NOT, RNR1, HZF-3 and TINUR. Its full name is nuclear receptor subfamily 4 group A member 2, and an earlier HGNC name was nuclear receptor subfamily 4, group A, member 2. NURR1 is the alias most often used in the literature.
NCBI Gene reports that NR4A2 mutations have been associated with Parkinson disease, schizophrenia and manic depression, and that misregulation may be associated with rheumatoid arthritis. Mouse and rat both carry an ortholog named Nr4a2; check the datasheet of any product for its validated reactivity.
Other NR4 subfamily members, nuclear hormone receptors and nuclear receptor-associated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P43354; product specifications from Assay Genie datasheets.