BOC
BOC (brother of CDO) is a cell-membrane protein of the immunoglobulin/fibronectin type III repeat family. It works with CDON as a coreceptor for sonic hedgehog signalling and contributes to myogenic cell interactions; it is also known as CDON2 or Boi. Browse Assay Genie's current range of BOC research reagents below, or read on for the biology behind the target.
BOC acts together with CDON to form a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor, PTCH1 or PTCH2. This handoff allows activation of the smoothened signalling pathway. In the current model, BOC binds the dually lipid-modified Sonic hedgehog N-product (ShhN) downstream of the SCUBE2 carrier and promotes its release to GAS1. GAS1 then transfers ShhN directly to the patched receptor.
BOC is also described as a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. In this setting it promotes differentiation of myogenic cells. The protein is a member of the immunoglobulin/fibronectin type III repeat family, and HGNC places the BOC gene in the fibronectin type III domain containing, I-set domain containing and Ig-like cell adhesion molecule groups. The protein localises to the cell membrane. Alternative splicing of the gene produces multiple transcript variants that encode different isoforms.
The HGNC name is BOC cell adhesion associated, oncogene regulated, and the protein is called Brother of CDO after its partner CDON. Earlier symbols and names include CDON2, Boi and Boc homolog (mouse). The mouse ortholog is Boc, so rodent models are available for work on hedgehog signalling and muscle differentiation. Researchers studying BOC often pair a BOC antibody, BOC ELISA kit or recombinant BOC protein with assays for its partners CDON, GAS1 and PTCH1.
BOC and CDON form a coreceptor needed to hand SHH to patched receptors, so BOC is central to studies of smoothened pathway activation.
BOC mediates cell-cell interactions between muscle precursor cells and promotes myogenic differentiation, making it relevant to muscle development studies.
BOC binds ShhN downstream of SCUBE2 and promotes its release to GAS1, offering a way to dissect stepwise transfer of lipid-modified SHH.
As an Ig-like cell adhesion family member with fibronectin type III repeats, BOC is used to study cell-surface receptor complexes.
BOC forms a coreceptor with CDON that is required for sonic hedgehog handoff to the patched receptor, allowing smoothened pathway activation. It binds ShhN and promotes its release to GAS1. It may also mediate cell-cell interactions between muscle precursor cells and promote myogenic differentiation.
BOC stands for brother of CDO, also written Brother of CDO. Aliases and previous symbols include CDON2 and Boi, and a previous name was Boc homolog (mouse). Alternative splicing gives multiple transcript variants that encode different isoforms, so check which isoform a reagent detects.
A mouse ortholog, Boc, is recorded, and the human gene was originally named as a homolog of it. This allows hedgehog and myogenesis studies in mouse models. Check the datasheet of any product for its validated reactivity.
Hedgehog pathway partners, patched receptors and related cell-surface coreceptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BWV1; product specifications from Assay Genie datasheets.