CCR1
CCR1 (C-C motif chemokine receptor 1, also known as CD191, CKR-1, MIP1aR, SCYAR1 and CMKBR1) is a cell-surface chemokine receptor that regulates immune cell migration, inflammation and immune responses. It belongs to the beta chemokine receptor family. Browse Assay Genie's current range of CCR1 research reagents below, or read on for the biology behind the target.
CCR1 is a chemokine receptor that plays a central role in directing immune cell migration. It contributes to the inflammatory response by recruiting monocytes, macrophages, T-cells and dendritic cells to sites of inflammation, supporting the clearance of pathogens and the resolution of tissue damage. When engaged by its ligands, including CCL3, CCL5-9, CCL13-16 and CCL23, it triggers a signalling cascade that drives cells towards the source of the chemokine.
Specific examples illustrate this. After activation by CCL3, CCR1 mediates neutrophil migration, leading to the sequential release of TNF and leukotriene B4. It also mediates monocyte migration on binding CXCL4, and activation by CCL5 results in neuroinflammation through the ERK1/2 signalling pathway. NCBI describes the receptor's ligands as including macrophage inflammatory protein 1 alpha (MIP-1 alpha), RANTES, monocyte chemoattractant protein 3 (MCP-3) and myeloid progenitor inhibitory factor-1 (MPIF-1).
The CCR1 gene encodes a seven-transmembrane protein of the G protein-coupled receptor 1 family, located at the cell membrane. HGNC classifies it among the CD molecules and the C-C motif chemokine receptors; its previous name was chemokine (C-C motif) receptor 1. The gene forms a cluster on chromosome 3p with other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1. Knockout studies of the mouse homologue, Ccr1, point to roles in host protection from inflammatory response and in susceptibility to virus and parasite.
CCR1 recruits monocytes, macrophages, T-cells and dendritic cells to inflamed tissue, making it a focus for studying how inflammatory responses develop and resolve.
Ligand binding by CCL3, CCL5 and others triggers directed migration, so CCR1 is used to examine chemokine-driven immune cell movement.
Activation of CCR1 by CCL5 results in neuroinflammation through ERK1/2 signalling, linking the receptor to neural inflammatory pathways.
Mouse Ccr1 knockout studies suggest roles in protection from inflammatory response and in susceptibility to virus and parasite.
CCR1 is a chemokine receptor that regulates immune cell migration and inflammation. Ligands such as CCL3 and CCL5 activate it, triggering signalling that moves monocytes, macrophages, T-cells, dendritic cells and neutrophils towards sites of inflammation.
CCR1 is also known as CD191, CKR-1, MIP1aR, SCYAR1 and CMKBR1. The HGNC name is C-C motif chemokine receptor 1, and the previous name was chemokine (C-C motif) receptor 1. MIP1aR reflects its binding of MIP-1 alpha.
Yes, the mouse ortholog is Ccr1. Knockout studies of the mouse homologue suggested roles in host protection from inflammatory response and in susceptibility to virus and parasite. Check the datasheet of any product for its validated reactivity.
Other chemokine receptors from the chromosome 3p cluster, and chemokine ligands that signal through CCR1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P32246; product specifications from Assay Genie datasheets.